Differences in the platelet proaggregatory activity of immune complexes isolated from patients with myocardial infarction or pulmonary cancer |
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| Authors: | G. Blaskó A. Pál N. Das L. M. Srivastava |
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| Affiliation: | 1. Medical Dept., Sanofi-Chinoin Ltd., Budapest, Hungary;2. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India |
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| Abstract: | Immune complexes were isolated immediately after the onset of the symptoms of myocardial infarction on an anti-Clq affinity column. The platelet proaggreagatory effects of these immune complexes were compared with those isolated from patients suffering from pulmonary cancer. A markedly increased proaggregatory effect of immune complexes derived from patients with myocardial infarction and changes in the sensitivity of platelets from healthy volunteers to PGI2 (prostacyclin) and PGD2 were found. In contrast, immune complexes from patients with pulmonary cancer did not show any significant effect. The antigenic part of immune complexes is probably relevant in the induction of platelet aggregation. |
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| Keywords: | immune complexes immune complex-induced aggregation myocardial infarction platelet aggregation pulmonary cancer |
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