Clinical observation on effect of shuanghuang shengbai granule on chemotherapy induced myelpsuppression in tumor patients and on ultrastructure of bone marrow in mice |
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| Authors: | Zhen-ye Xu Yan-wei Zhu Wei-dong Zhou Hui Zhang Yan-fang Ju Li-hong Zhao Hai-bin Deng Ji Wu De-yi Shen and Hui-xin Zhang |
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| Institution: | (1) Department of Community Health Sciences, The Aga Khan University, Karachi, Pakistan;(2) Sindh Environmental Protection Agency, Karachi, Pakistan;(3) Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA |
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| Abstract: | To observe the leucocyte increasing effect of Shuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy and the bone marrow microenvironment protecting effect in mice. Methods Patients of non-small-cell pulmonary, mammary, gastric or intestinal cancer, who were ready for receiving re-treatment of chemotherapy, were enrolled and divided into 4 groups randomly. The 28 cases in SHSBG group A received chemotherapy combined with SHSBG; the 27 in the SHSBG group B received chemotherapy alone at first, and SHSBG was added when their peripheral white blood cell (WBC) count lowered to <4×109/L; the 33 in control group A and 24 in control group B were treated by the method similar to that applied to SHSBG group A and B respectively but with Rubidate instead of SHSBG. Experimental study of electron microscopic observation on bone marrow ultrastructure in mice was also conducted. |
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