明胶海绵栓塞建立实验动物急性脑梗死模型

目的 探讨明胶海绵栓塞猴颈内动脉复制急性脑梗死模型的可行性。方法选用成年猴6只，经股动脉穿刺插管，明胶海绵栓塞颈内动脉，然后行数字减影血管造影（DSA）显示血管闭塞情况，栓塞后3h，4h，6h，8h，12h，24hCT平扫，观察脑梗死CT表现。结果6只猴栓塞后DSA显示颈内动脉闭塞，大脑前、中动脉未显影。栓塞后6hCT平扫可见栓塞侧大脑半球片状低密度坏死区。结论用明胶海绵栓塞颈内动脉复制急性脑梗死模型可行。

Establishment of acute cerebral infarction model in experimental animal with gelfoam embolization

Objective To explore the feasibility of establishing acute cerebral infarction model in experimental animal with gelfoam embolization for internal calotid artery(ICA).Methods Six adult monkeys used as the expeimental model underwent femoral artery catheterization with seldinger' s technique and superselective ICA embolization with gelfoam,and then all monkeys underwent additional digital subtraction angiography (DSA)to show cerebrovascular occlusion state.In order to observe the CT findings of monkeys with acute cerebral infarction,CT plain scans were performed at 3,4,6,8,12 and 24 hours after the embolization.Results Following ICA embolization,DSA showed the occlusion of ICA in 6 monkeys but their anterior and middle cerebral arteries had not development. CT plain scan images showed lower- intensive necrotic areas within the embolic side of cerebral hemisphere after embolization for 6 hours. Conclusion Using gelfoam embolization for ICA to establish the acute cerebral infarcion model is feasible.