The Genotoxic Potential of Linear Alkylbenzene Mixtures in a Short-Term Test Battery |
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Authors: | ROBINSON E C; NAIR R S |
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Institution: | Department of Medical and Health Sciences, Monsanto Company St. Louis, Missouri 63167
Received June 10, 1991;
accepted November 1, 1991 |
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Abstract: | Alkylate 215 (A-215), Alkylate 225 (A-225), and Alkylate 230(A-230) are mixtures of C10C14 linear alkylbenzenes usedas intermediates for the manufacture of detergents. These productswere evaluated for genotoxic activity in the Ames bacterialmutagenesis assay (strains TA98, 100, 1535, and 1537), the CHO/HGPRTmammalian cell forward gene mutation assay, and the in vivorat bone marrow chromosome assay. The Ames and CHO/HGPRT assayswere conducted both with and without the addition of Aroclor-inducedrat liver S9. The maximum concentrations evaluated were 10 mg/plate(A-215) and 3 mg/plate (A-225 and A-230) for the Ames test,and 1.5 mg/ml (A-215 and A-225) and 2.0 mg/ml (A-230) for theCHO/HGPRT assay. In each case, the highest concentrations producedevidence of either toxicity or insolubility. The highest dosein the bone mar row cytogenetics assay was 12,700 mg/kg, a levelwhich produced significant weight loss. The results of all testswere negative, indicating a lack of genotoxic activity as measuredby the battery of tests used. |
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