| 胃液对膀胱癌细胞系Bcl-2/Bax表达的影响 |
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| 引用本文： | 田斌群,胡礼泉,郑新民,姚学军,李世文,王家治,张国辉. 胃液对膀胱癌细胞系Bcl-2/Bax表达的影响[J]. 肿瘤防治研究, 2000, 27(1): 43-45 |
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| 作者姓名： | 田斌群 胡礼泉 郑新民 姚学军 李世文 王家治 张国辉 |
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| 作者单位： | 1. 湖北医科大学附属第二医院泌尿外科,武汉,430071
2. 湖北医科大学病毒研究所 |
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| 基金项目： | 湖北省教委资助!(G - 91- 12 ) |
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| 摘 要： | 目的 为了探讨胃液诱导膀胱癌细胞系细胞凋亡的机制。方法 采用流式细胞术及免疫组化方法观察了胃液对膀胱癌细胞系BIU-87细胞凋亡及Bcl-2/Bax表达的影响。结果 显示胃液处理后AI值升高，Bcl-2表达降低，Bax表达升高，Bcl-2/Bax比值为0.71。结论 提示胃液诱导BIU-87细胞凋亡可能是通过降低Bcl-2，升高Bax而实现的。
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| 关 键 词： | 胃液 膀胱癌细胞系 细胞凋亡 Bcl-2/Bax |
| 文章编号： | 1000-8578(2000)01-0043-03 |
| 收稿时间： | 1900-01-01; |
Effect of Gastric Juice on Bcl-2/Bax Expression of Human Bladder Cancer Cell Line |
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| TIAN Bin-qun. Effect of Gastric Juice on Bcl-2/Bax Expression of Human Bladder Cancer Cell Line[J]. Cancer Research on Prevention and Treatment, 2000, 27(1): 43-45 |
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| Authors: | TIAN Bin-qun |
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| Affiliation: | Department of Urology,The Second Affiliated Hospital,Hubei Medical University,Wuhan 430071,China |
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| Abstract: | Objective To study the mechanism of apoptosis induced by gastric juice.Methods Flow cytometry and immunohistochemistry were utilized to observe the effect of gastric juice on Bcl 2/Bax expression of human bladder cancer cell line BIU 87.Results After administration of gastric juice,AI increased,Bcl 2 expression reduce,Bax expression increased and Bcl 2/Bax ratio was 0 71.Conclusion It was suggested that gastric juice could induce the apoptosis of BIU 87 by reducing Bcl 2 and increasing Bax. |
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| Keywords: | Gastric juice Bladder cancer cell line Apoptosis Bcl 2/Bax |
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