The effect of ciprofibrate on gastric secretion in the rat |
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| Authors: | C T Eason A Pattison D D Howells F W Bonner |
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| Affiliation: | Toxicology Department, Sterling-Winthrop Research Centre, Alnwick, Northumberland, UK. |
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| Abstract: | The potential of ciprofibrate to inhibit gastric secretion has been investigated in the rat. A significant gastric antisecretory effect was observed following a single oral administration of 300 and 500 mg kg-1 and following a single intraduodenal dose of 100, 300 and 500 mg kg-1. The toxicological significance of this finding is discussed in the light of a spate of recent publications linking changes in gastric morphology with hypergastrinaemia produced as a secondary effect of inhibition of acid secretion. |
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