An analysis of peripheral type benzodiazepine receptors on blood mononuclear cells during high dose steroid treatment of multiple sclerosis |
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Authors: | P Ferrero P Rocca P Benna C De Leo E Montalenti L Ravizza and B Bergamasco |
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Institution: | (1) Istituto di Clinica delle Malattie del Sistema Nervoso dell'Università di Torino, Torino, Italy;(2) Istituto di Clinica Psichiatrica dell'Università di Torino, Torino, Italy;(3) Clinica Neurologica, Via Cherasco 15, 10126 Torino |
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Abstract: | We report here a study of peripheral type benzodiazepine receptors (pBZr) in mononuclear cells (MNC) from blood of patients
with multiple sclerosis (MS) during periods of stable and active disease and from normal controls. Most active MS patients
were retested in a longitudinal study, both during a treatment with high dose steroids and while medication free. Active MS
produces a significant decrease of receptor density compared with the controls whereas remission of the disease shows no effect.
Four weeks of steroid treatment restore binding density to normal levels, and two weeks of drug withdrawal result in a small,
but significant increase in number of the binding sites compared with the control value. We suggest that the number of pBZr
in blood MNC might change during the clinical course and steroid therapy of MS.
Paper presented at the National Congress at Sorrento in 1991 and selected by the Editorial Board of the Journal |
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Keywords: | Multiple sclerosis peripheral benzodiazepine receptors mononuclear cells |
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