| 口腔癌相关成纤维细胞对舌癌细胞株侵袭特性的影响 |
| |
| 引用本文： | 林靖雯,周红梅,李胜富,胡涛,陈谦明. 口腔癌相关成纤维细胞对舌癌细胞株侵袭特性的影响[J]. 华西口腔医学杂志, 2006, 24(2): 101-103 |
| |
| 作者姓名： | 林靖雯 周红梅 李胜富 胡涛 陈谦明 |
| |
| 作者单位： | 口腔生物医学工程教育部重点实验室,四川大学;四川大学华西口腔医院,黏膜科;四川大学华西医院,卫生部移植工程和移植免疫重点实验室,四川,成都,610041 |
| |
| 基金项目： | 中国科学院资助项目;广东省博士启动基金 |
| |
| 摘 要： | 目的 采用重建基底膜细胞侵袭实验，研究直接分离自舌癌组织旁的癌相关成纤维细胞（CAFs）对舌癌细胞株侵袭特性的影响，探讨CAFs在口腔鳞癌发展中的作用。方法 以Matrigel模拟重建基底膜，采用Transwell小室建立口腔CAFs与舌癌细胞株Tca8113的交互作用模型，观测CAFs对Tca8113侵袭特性的影响。结果 与正常成纤维细胞（NFs）相比，CAFs能促使更多的Tca8113细胞穿透Matrigel（P<0.05）。结论 口腔CAFs能促进舌癌细胞株Tca8113
的侵袭，在口腔鳞癌发展中起重要作用。
|
| 关 键 词： | 癌相关成纤维细胞 口腔 癌细胞株 侵袭 |
| 文章编号： | 1000-1182（2006）02-0101-03 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2006-02-16 |
The Effect of Oral Carcinoma-associated Fibroblasts on the Invasion of Carcinoma Cell Line |
| |
| LIN Jing-wen,ZHOU Hong-mei,LI Sheng-fu,HU Tao,CHEN Qian-ming. The Effect of Oral Carcinoma-associated Fibroblasts on the Invasion of Carcinoma Cell Line[J]. West China journal of stomatology, 2006, 24(2): 101-103 |
| |
| Authors: | LIN Jing-wen ZHOU Hong-mei LI Sheng-fu HU Tao CHEN Qian-ming |
| |
| Affiliation: | 1. Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China; 2. Dept. of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China; 3. Laboratory of Transplantation Engi- neering and Transplantation Immunity, West China Hospital, Sichuan University, Chengdu 610041, China |
| |
| Abstract: | Objective To observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression. Methods Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113. Results Compared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P<0.05). Conclusion Oral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression. |
| |
| Keywords: | carcinoma-associated fibroblasts oral carcinoma cell line invasion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《华西口腔医学杂志》浏览原始摘要信息 |
|
点击此处可从《华西口腔医学杂志》下载免费的PDF全文 |
|
