老年性骨质疏松症的证候特征及相关危险因素的分析

目的 探讨老年性骨质疏松症的证候特征及其相关危险因素.方法 对98名老年性骨质疏松症患者进行中医证候评定,以39例骨密度正常老年人作对照,Logistic回归分析等统计学方法用于相关危险因素的分析.结果 老年性骨质疏松症最常出现的中医证候是气虚证、肾精亏虚证;较常出现的证候是瘀血证和痰浊证.气虚证是老年性骨质疏松症的独立危险因素;如果考虑两种病理因素合而为病,则肾精亏虚与阴虚是老年性骨质疏松症的危险因素,脾气虚与瘀血阻络两两交互作用,发生骨质疏松症的危险性更高.结论 骨密度与气虚证、脾虚血瘀证、肾虚阴亏证具有密切关系,气虚、肾虚阴亏、脾虚血瘀是老年性骨质疏松症的基本病理因素.

Symptom characteristics of osteoporosis and related risk factors

Objective To investigate the characteristics of TCM syndromes of osteoporosis (OP) and related risk factors. Method The TCM syndromes were evaluated in 98 old patients with OP, and other 39 patients with normal bone mineral density (BMD) were taken as the control. The Logistic regressive analysis was used to analyze the related risk factors. Result The most common syndromes in OP were qi-insufficient syndrome and kidney-essence deficient syndrome, and common syndromes were blood-stasis syndrome and phlegm syndrome. The syndrome of qi- insufficient was an independent risk factor. If two pathological factors were combined the risk factors of OP would be kidney-essence deficiency and yin-deficiency. When the syndromes of spleen-qi insufficiency and collateral obstruction by blood stasis interacted each other the risk of OP would be higher. Conclusion BMD is closely related to the syndromes of qi insufficiency, spleen insufficiency and blood stasis, and kidney-essence and yin-deficiency. The qi insufficiency, kidney-essence and yin-deficiency, and spleen insufficiency and blood stasis are the basic pathological factors of osteoporosis.