脑肿瘤患者尿表皮生长因子检测及其临床意义

目的：检测脑肿瘤患者尿中表皮生长因子（epidermal growth factor，EGF）的含量并探讨其临床意义。方法：采用放射免疫分析方法检测20例脑肿瘤患者尿中EGF的含量，其中脑星形细胞瘤15例（WHO分级1～2级6例，3～4级9例）和脑膜瘤患者5例，手术前后各检测1次，以健康正常人（n=5）作对照。结果：手术前，与脑膜瘤患者和健康人相比，脑星形细胞瘤患者尿EGF含量明显增高（P〈0．01），且WHO分级3～4级患者尿EGF含量较1～2级者明显增高（P〈0．05）；手术后，脑星形细胞瘤患者尿EGF含量明显下降（P〈0.01）；而脑膜瘤患者尿EGF含量在手术前后无明显变化，与对照组相比，差异均无统计学意义。结论：脑星形细胞瘤患者尿EGF水平与病理级别相关，且其纵向变化与手术治疗前后同步，提示尿EGF含量的检测对星形细胞瘤的诊断和治疗效果评价有实际指导意义。

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Objective To investigate the clinical significance of urinary epidermal growth factor(EGF) in patients with brain tumors.Methods The levels of EGF in urine samples collected from 20 patients(9 low grade astrocytomas,6 anaplastic astrocytomas,and 5 meningiomas) and 5 healthy individuals were determined.EGF levels were measured by radioimmunoassay technique.A preoperative and one postoperative determination were performed.Results Preoperative urinary EGF levels of astrocytoma patients were statistically higher than those of meningioma patients and the controls(P<(0.01).) Preoperative urinary EGF levels showed a positive correlation with the degree of malignance in the astrocytoma patients(P<0.05).A significant decrease of the postoperative levels of EGF was observed in the astrocytoma patients who underwent gross total resection(P<(0.01).) The pre/postoperative urinary EGF levels of the meningioma patients showed no significant fluctuations and showed no significant difference with those of healthy individuals(P>0.05).Conclusion The urinary EGF levels of astrocytoma patients correlate with the WHO grade of malignance and significantly decrease after gross total removal.Urinary EGF may be of practical value in diagnosing and evaluating the surgical efficacy of astrocytomas.