福州地区健康体检女性HPV-DNA检测联合宫颈液基细胞学检查对宫颈病变筛查的结果分析

目的 分析健康体检女性宫颈癌筛查人群HPV感染情况及与宫颈病变的关系,筛查并识别目标人群。方法 选取2018年1月～2020年1月福建省立医院9355例行HPV-DNA检测联合宫颈液基细胞学检查(Thinprep cytologic test,TCT)的健康体检女性为研究对象。结果 9355例受检者中,HPV感染1366例,感染率为14.60%,检出全部27种HPV亚型;高危型HPV前5位的亚型依次是HPV 52、HPV 58、HPV 53、HPV 56、HPV 39;单一感染1057例(77.38%),多重感染中二重感染最常见(17.42%)。宫颈改变219例(2.34%),165例合并HPV感染,感染率为74.43%;在LSIL、HSIL、SCC中,高危型HPV感染率分别为80.00%、96.00%、100.00%,单一感染率分别为62.50%、84.00%、100.00%,HPV16占比分别为7.50%、28.00%、100.00%(P0.05)。46～50岁高危型HPV、单一感染和多重感染人数最多;AGO、ASC-US、LSIL在此组最多。LSIL及以上级别宫颈病变以51～55岁最多。结论 福州地区宫颈癌筛查的目标人群是46～55岁女性,加强对此年龄段宫颈癌筛查女性健康管理、转诊、随访有重要意义。

Analysis of the results of HPV-DNA detection combined with cervical fluid-based cytology examination for cervical lesion screening in healthy physical examination women in Fuzhou

Objective To analyze the HPV infection status and its relationship with cervical lesions in the cervical cancer screening population of healthy physical examination women,and to screen and identify the target population.Methods A total of 9355 patients who underwent HPV-DNA testing combined with cervical liquid-based cytology(thinprep cytologic test,TCT) in Fujian Provincial Hospital from January 2018 to January 2020 were selected as the research subjects.Results Among 9355 subjects,1366 cases were infected with HPV,with infection rate of 14.60%,and all 27 HPV subtypes were detected.The top 5 subtypes of high-risk HPV were HPV52,HPV 58,HPV 53,HPV 56 and HPV 39.There were 1057 cases(77.38%) with single infection,and double infections were the most common among multiple infections(17.42%).There were 219 cases(2.34%) with cervical changes,165 cases with HPV infection,and the infection rate was 74.43%.In LSIL,HSIL,SCC,high-risk HPV infection rates were 80.00%,96.00%,100.00%,and single infection rate was 62.50%,84.00%,100.00%,and HPV16 accounted for 7.50%,28.00%,100.00%(P<0.05).The 46-50 age had the highest number of high-risk HPV,single infection,and multiple infections.AGO,ASC-US,and LSIL had the largest number in this group.Cervical lesions with LSIL and above were the most in the 51-55 age.Conclusion The target population for cervical cancer screening in Fuzhou is women aged 46-55 age.It is of great significance to strengthen the health management,referral and follow-up of women of cervical cancer screening at this age.