DcR3、EMMPRIN、RANKL与绝经后类风湿关节炎患者骨密度的相关性分析

目的分析诱骗受体3(DcR3)、细胞外基质金属蛋白酶诱导因子(EMMPRIN)、核因子-кB受体活化因子配体(RANKL)与绝经后类风湿关节炎患者骨密度(BMD)的相关性。方法选取2018年1月-2019年1月该院收治的绝经后类风湿关节炎患者80例作为类风湿关节炎组,另外选取同期在该院行健康体检的80例健康绝经后女性作为健康对照组。检测所有研究对象DcR3表达水平、RANKL表达水平、EMMPRIN蛋白表达量及BMD,分析DcR3、EMMPRIN、RANKL与BMD之间的相关性。结果类风湿关节炎组DcR3、EMMPRIN、RANKL水平均高于健康对照组,BMD低于健康对照组,差异有统计学意义(P<0.05)。高度活动组、中度活动组DcR3、EMMPRIN、RANKL水平均高于低缓组,BMD低于低缓组,差异有统计学意义(P<0.05);高度活动组DcR3、EMMPRIN、RANKL水平均高于中度活动组,BMD低于中度活动组,差异有统计学意义(P<0.05)。DcR3、EMMPRIN之间呈正相关(r=0.426,P=0.001);DcR3、RANKL之间呈正相关(r=0.391,P=0.001);EMMPRIN、RANKL之间呈正相关(r=0.385,P=0.001)。DcR3与BMD之间呈负相关(r=-0.392,P=0.001);EMMPRIN与BMD之间呈负相关(r=-0.375,P=0.001);RANKL与BMD之间呈负相关(r=-0.222,P=0.048)。结论DcR3、EMMPRIN、RANKL在绝经后类风湿关节炎患者中高表达,疾病越严重其表达越加剧,且与患者BMD相关,参与疾病的发生发展。

Correlation analysis of DcR3,EMMPRIN,RANKL and bone mineral density in postmenopausal rheumatoid arthritis

Objective The relationship between decoy receptor 3(DcR3),extracellular matrix metalloproteinase inducer(EMMPRIN),nuclear factorкB receptor activator ligand(RANKL)and bone mineral density(BMD)in postmenopausal rheumatoid arthritis was analyzed.Methods 80 patients with postmenopausal rheumatoid arthritis admitted to our hospital from January 2018 to January 2019 were selected as the rheumatoid arthritis group,and 80 healthy postmenopausal women who had physical examination in our hospital at the same time were selected as the healthy control group.The expression level of DcR3,RANKL,EMMPRIN protein and BMD of all subjects were detected,and the correlation between DcR3,EMMPRIN,RANKL and BMD was analyzed.Results The levels of DcR3,EMMPRIN and RANKL in RA group were higher than those in healthy control group,and BMD was lower than that in healthy control group(P<0.05).The levels of DcR3,EMMPRIN and RANKL in high activity group and moderate activity group were higher than those in low activity group,and BMD was lower than that in low activity group,with statistical significance(P<0.05);the levels of DcR3,EMMPRIN and RANKL in high activity group were higher than that in moderate activity group,and BMD was lower than that in moderate activity group,with statistical significance(P<0.05).DcR3 and EMMPRIN are positively correlated(r=0.426,P=0.001);DcR3 and RANKL are positively correlated(r=0.391,P=0.001);EMMPRIN and RANKL are positively correlated(r=0.385,P=0.001).DcR3 was negatively correlated with BMD(r=-0.392,P=0.001);EMMPRIN was negatively correlated with BMD(r=-0.375,P=0.001);RANKL was negatively correlated with BMD(r=-0.222,P=0.048).Conclusion DcR3,EMMPRIN and RANKL are highly expressed in patients with postmenopausal rheumatoid arthritis.The more serious the disease is,the more severe the expression is DcR3,EMMPRIN and RANKL are related to the bone mineral density of the patient and participate in the occurrence and development of the disease.