子宫内膜雌、孕激素受体水平与子宫内膜息肉发病的相关性研究

目的研究子宫内膜雌激素受体(ER)、孕激素受体(PR)水平与子宫内膜息肉(EP)发病的相关性。方法选择2018年6月-2019年6月锦州医科大学附属第一医院收治的63例EP患者作为观察组,同期体检无子宫内膜疾病63例妇女作为对照组。比较两组患者ER和PR水平,分析ER、PR水平与EP发病的相关性和对EP的诊断价值。结果观察组与对照组相比子宫内膜腺体ER、PR表达存在显著性差异(P<0.05)。子宫内膜间质中ER在两组中表达无明显差异(P>0.05),子宫内膜间质PR表达在两组中存在显著性差异(P<0.05)。内膜腺体ER、PR水平与EP发病分别呈正相关性(P<0.05)和负相关性(P<0.05)。内膜间质ER水平与EP发病无相关性(P>0.05),间质PR水平与EP发病呈负相关性(P<0.05)。腺体ER、PR水平联合检测诊断的受试者操作特征曲线(ROC)曲线下面积(AUC)为0.827,明显大于腺体ER、PR水平分别单独诊断的AUC 0.737和0.766(均P<0.05)。间质ER、PR水平联合检测诊断的AUC为0.744,明显大于间质ER水平单独诊断时的AUC 0.583(P<0.05),与间质PR水平单独诊断的AUC 0.736无明显差异(P>0.05)。结论EP发生与腺体ER、腺体和间质PR表达情况相关,与间质ER表达情况无关。腺体ER、PR水平联合检查提高了诊断效能。

Correlation between endometrial estrogen receptor,progesterone receptor levels and endometrial polyps onset

Objective To study correlation between endometrial estrogen receptor(ER),progesterone receptor(PR)levels and endometrial polyps(EP).Methods 63 EP patients who were admitted to the hospital from June 2018 to June 2019 were enrolled as observation group.63 women without endometrial disease who underwent physical examination were enrolled as control group.ER and PR levels were compared between the two groups.The correlation between ER,PR levels and EP onset,and their diagnostic value in EP were analyzed.Results There were significant differences in expression of endometrial ER and PR between observation group and control group(P<0.05).There was no significant difference in expression of ER in endometrial mesenchyma between the two groups(P>0.05),while there were significant differences in expression of PR in endometrial mesenchyma between the two groups(P<0.05).The intima gland ER level was positively correlated with EP onset(P<0.05),while intima gland PR was negatively correlated with EP onset(P<0.05).There was no correlation between intima interstitial ER level and EP onset(P>0.05),while mesenchyma PR level was negatively correlated with EP onset(P<0.05).AUC[area under ROC(receiver operating characteristic)curve]of combined detection with gland ER and PR levels was 0.827,which was significantly higher than that of their single diagnosis(0.737,0.766)(AllP<0.05).AUC of combined detection with mesenchyma ER and PR levels was 0.744,which was significantly higher than that of mesenchyma ER(0.583)(P<0.05).There was no significant difference in AUC between combined detection and mesenchyma PR level(0.736)(P<0.05).Conclusion The occurrence of EP is related to expression of gland ER,gland and mesenchyma PR,while not related to expression of mesenchyma ER.Combination examination of gland ER and PR levels improves diagnostic efficiency.