肺腺癌组织中IGF1R、Cezanne-1表达与EGFR基因突变的相关性分析

目的探讨肺腺癌组织中胰岛素样生长因子-1受体(IGF1R)、Cezanne-1表达与表皮生长因子受体(EGFR)基因突变情况，分析IGF1R、Cezanne-1表达与EGFR基因突变的相关性。 方法选择2017年3月至2019月4月本医经病理确诊且得到明确肺腺癌肿瘤组织与癌旁组织的肺腺癌患者56例，将其纳入病例组；纳入同期在医院接受手术治疗并在术中获得病灶组织的51例肺部良性病变患者，将其作为对照组。对全部纳入的组织样本进行IGF1R、Cezanne-1表达与EGFR基因突变检查，比较各组IGF1R、Cezanne-1阳性表达与EGFR基因突变检出率；比较不同EGFR基因突变肺腺癌患者临床特征、IGF1R、Cezanne-1阳性检出率；分析IGF1R、Cezanne-1表达与EGFR基因突变的相关性。 结果肺腺癌组织EGFR基因突变、IGF1R、Cezanne-1阳性检出率均高于癌旁组织及肺部良性病变组，差异有统计学意义(P<0.05)；EGFR基因突变的肺腺癌患者与其他未检出基因突变的肺腺癌患者的临床特征比较，差异均无统计学意义(P>0.05)，但较未检出EGFR基因突变的肺腺癌组织，检出基因突变的组织中IGF1R、Cezanne-1阳性检出率更高，差异有统计学意义(P<0.05)；IGF1R、Cezanne-1表达与EGFR基因突变之间均呈正相关(r>0，P<0.05)。 结论肺腺癌组织内IGF1R、Cezanne-1多呈过表达，EGFR基因突变率较其他正常组织高，且这种IGF1R、Cezanne-1的过表达与EGFR基因突变明显相关。

Correlation between expression levels of insulin-like growth factor-1 receptor and Cezanne-1 and epidermal growth factor receptor gene mutations in lung adenocarcinoma tissues

ObjectiveTo analyze the correlation between the expression levels of insulin-like growth factor-1 receptor (IGF1R) and Cezanne-1 and the gene mutations of epidermal growth factor receptor (EGFR) in lung adenocarcinoma tissues. MethodsClear lung adenocarcinoma tissues and para-carcinoma tissues obtained from the 56 patients with lung adenocarcinoma who were pathologically diagnosed in our hospital from March 2017 to April 2019 were included in the case group, and lesion tissues from the 51 patients with benign pulmonary lesions who underwent surgical treatment during the same period were included in the control group. The expression levels of IGF1R and Cezanne-1 and EGFR gene mutations of all the included tissue samples were examined, and the detection rates of IGF1R and Cezanne-1 positive expression and EGFR gene mutations were compared between the two groups. The clinical features, the positive detection rates of IGF1R and Cezanne-1 expression of the lung adenocarcinoma patients with different EGFR gene mutations were compared. The correlation between the expression levels of IGF1R and Cezanne-1 and EGFR gene mutations was analyzed, too. ResultsThe positive detection rates of EGFR gene mutations and the expression levels of IGF1R and Cezanne-1 in the lung adenocarcinoma tissues were higher than those of the para-carcinoma tissues and the benign pulmonary lesions (P<0.05). There was no statistical significant difference in the clinical features between the lung adenocarcinoma patients with EGFR gene mutations and the lung adenocarcinoma patients without gene mutations (P>0.05). However, compared with the lung adenocarcinoma tissues without EGFR gene mutations, the positive detection rates of IGF1R and Cezanne-1 expression in the tissues with gene mutations were higher (P<0.05). The IGF1R and Cezanne-1 expression had positive correlations with EGFR gene mutations (r>0, P<0.05). ConclusionThe IGF1R and Cezanne-1 are over-expressed in the lung adenocarcinoma tissues, and the EGFR gene mutation rate is higher than that of other normal tissues. Moreover, the over-expression of IGF1R and Cezanne-1 is significantly related to EGFR gene mutations.