妊娠期糖尿病患者血清鸢尾素水平与糖脂代谢、妊娠结局的相关性

目的探讨妊娠期糖尿病(GDM)患者血清鸢尾素水平与糖脂代谢、妊娠结局的相关性。方法选取2017年4月-2019年4月接受产检并确诊为GDM的孕妇90例为GDM组,根据血清鸢尾素水平分为高鸢尾素组、低鸢尾素组,每组45例。选取同期进行产检的健康孕妇100例为对照组。采用酶联免疫吸附法检测血清鸢尾素水平。检测糖代谢指标、脂代谢指标水平。比较高鸢尾素组、低鸢尾素组孕妇的妊娠结局和胎儿/新生儿结局。结果 GDM组孕妇血清鸢尾素水平为(6. 59±0. 82) ng/ml,显著高于对照组孕妇[(4. 11±0. 56) ng/ml](P <0. 05)。GDM组孕妇血清空腹血糖(FPG)、空腹胰岛素(Fins)、糖化血红蛋白(Hb A1c)水平均高于对照组,高鸢尾素组孕妇血清FPG、Fins、Hb A1c水平均高于低鸢尾素组,差异均有统计学意义(P<0. 05)。GDM组与对照组孕妇血清脂代谢指标水平比较差异有统计学意义,高鸢尾素组和低鸢尾素组孕妇血清脂代谢指标水平比较差异有统计学意义(P<0. 05)。高鸢尾素组和低鸢尾素组孕妇剖宫产率比较差异有统计学意义(P<0. 05)。高鸢尾素组巨大儿和新生儿窒息发生率均高于低鸢尾素组(P<0. 05)。结论 GDM患者血清鸢尾素水平与病情严重程度存在直接相关关系,对妊娠结局也有一定预测价值。

Correlations between serum irisin level and glucose metabolism,lipid metabolism,pregnancy outcome in patients with gestational diabetes mellitus

Objective To explore the correlations between serum irisin level and glucose metabolism,lipid metabolism,pregnancy outcome in patients with gestational diabetes mellitus( GDM). Methods Ninety pregnant women receiving prenatal examination and diagnosed as GDM from April 2017 to April 2019 were selected as GDM group,then they were divided into high irisin group and low irisin group according to serum irisin level. One hundred healthy pregnant women receiving prenatal examination during the same period were selected as control group. ELISA was used to detect serum irisin level,the levels of glucose metabolism indexes and lipid metabolism indexes were detected. Pregnancy outcomes,fetal/neonatal outcomes were compared between high irisin group and low irisin group. Results Serum irisin level in GDM group was( 6. 59±0. 82) ng/ml,which was statistically significantly higher than that in control group [( 4. 11±0. 56) ng/ml]( P<0. 05). The levels of fasting plasma glucose( FPG),fasting insulin( Fins),and glycosylated hemoglobin( Hb A1 c) in GDM group were statistically significantly higher than those in control group,the levels of serum FPG,Fins,and Hb A1 c in high irisin group were statistically significantly higher than those in low irisin group( P<0. 05). There were statistically significant differences in the levels of serum lipid metabolism indexes between GDM group and control group,there were statistically significant differences in the levels of serum lipid metabolism indexes between high irisin group and low irisin group( P<0. 05). There was statistically significant difference in cesarean section rate between high irisin group and low irisin group( P<0. 05). The incidence rates of macrosomia and neonatal asphyxia in high irisin group were statistically significantly higher than those in low irisin group( P<0. 05). Conclusion Serum irisin level in patients with GDM is directly correlated with the severity of the disease,and it has a certain predictive value for pregnancy outcome.