小脑血管畸形的临床特点及手术治疗的疗效分析

目的 分析小脑血管畸形的临床特点及手术治疗的临床疗效。方法 选择2016年8月～2019年8月我院收治的32例小脑血管畸形患者,随机平均分为两组,对照组16例患者采用开颅血管畸形切除术治疗,实验组16例患者采用血管内介入栓塞术治疗,比较两组的临床疗效、GOS评分、血清MMP-2、MMP-9水平、并发症发生情况。结果 实验组临床总有效率(93.75%)显著高于对照组(56.25%)(P0.05);术前两组GOS评分比较,差异无统计学意义(P0.05),两组术后7 d GOS评分均高于术前(P0.05),术后实验组7 d GOS评分显著高于对照组(P0.05);术前两组血清MMP-2、MMP-9水平比较,差异无统计学意义(P0.05),两组术后7 d血清MMP-2、MMP-9水平均低于术前,术后实验组7 d血清MMP-2、MMP-9水平均显著低于对照组(P0.05);实验组并发症发生率(6.25%)显著低于对照组(37.50%)(P0.05)。结论 小脑血管畸形患者实施血管内介入栓塞术治疗,可有效减轻昏迷程度,降低血清MMP-2、MMP-9含量,且并发症发生率较低,值得应用。

Clinical features of cerebellar vascular malformations and efficacy of surgical treatment

Objective To analyze the clinical features of cerebellar vascular malformations and the clinical efficacy of surgical treatment.Methods A total number of 32 patients with cerebellar vascular malformation treated in our hospital from August 2016 to August 2019 were included.They were randomly divided into two groups,with 16 patients in the control group who were treated with cranial resection of cerebellar vascular malformation and 16 patients in the experimental group who were treated with intravascular interventional embolization.The clinical efficacy,GOS score,levels of serum MMP-2 and MMP-9,and complications were compared between the two groups.Results The total clinical effective rate of the experimental group (93.75%) was significantly higher than that of the control group (56.25%) (P<0.05).The GOS scores of the two groups before surgery showed P>0.05.The GOS scores of the two groups at 7 days after surgery were higher than those before surgery(P<0.05).The GOS score of the experimental group was significantly higher than that of the control group at 7 days after surgery(P<0.05).The levels of serum MMP-2 and MMP-9 of the two groups before surgery showed P>0.05.The levels of serum MMP-2 and MMP-9 of the two groups at 7 days after surgery were lower than those before surgery(P<0.05).The levels of serum MMP-2 and MMP-9 of the experimental group were significantly lower than those of the control group at 7 days after surgery.The incidence of complications in the experimental group(6.25%) was significantly higher than that in the control group(37.50%) (P<0.05).Conclusion Intravascular interventional embolization for the treatment of cerebellar vascular malformations can effectively lower the degree of coma,the levels of serum MMP-2 and MMP-9,and the incidence of complications,which is worthy of attention in clinical practice.