托特罗定治疗直肠癌术后排尿功能障碍患者的效果观察

目的 探讨托特罗定在直肠癌术后排尿功能障碍患者中的应用效果。方法 选择2016年2月～2019年6月期间于我院接受治疗的85例直肠癌术后排尿功能障碍患者,采用随机数字表法分为对照组(n=42)与观察组(n=43)。两组均连续治疗8周,观察两组治疗前后排尿功能障碍分级,并比较两组治疗前后尿动力学指标,同时记录两组治疗期间不良反应发生情况。结果 治疗8周后,两组入选者排尿功能障碍分级均低于治疗前,且与对照组相比,观察组更低,差异有统计学意义(P0.05);治疗8周后,两组入选者最大尿流率(Mean maximal flow rate,Qmax)、排尿量(Mean voided volume,Vcomp)、最大尿道压(Maximum urethral pressure,MUP)水平均高于治疗前,残余尿量(RVU)水平均低于治疗前,且与对照组相比,观察组Qmax、Vcomp、MUP水平更高,RVU水平更低,差异有统计学意义(P0.05);观察组不良反应发生率(9.30%)与对照组(0.00%)比较,差异无统计学意义(P0.05)。结论托特罗定治疗直肠癌术后排尿功能障碍患者效果显著,利于减轻患者排尿功能障碍,改善尿动力学指标及膀胱过度活动症状,且不良反应较少。

Observation of the effect of tolterodine on patients with rectal cancer postoperative dysuria

Objective To explore the application effect of tolterodine in patients with rectal cancer postoperative dysuria.Methods Eighty-five patients with rectal cancer postoperative dysuria treated in our hospital from February 2016 to June 2019 were selected.They were divided into the control group(n=42) and the observation group(n=43) by random number table method.Both groups were treated continuously for 8 weeks.The dysuria grading before and after treatment between two groups was observed.The urodynamic indexes before and after treatment between two groups were compared,and the occurrence of adverse reactions during treatment between two groups was recorded.Results After 8 weeks of treatment,the dysuria grade of the two groups were lower than before treatment,and compared with that of the control group,the grade of the observation group was lower,and the difference was statistically significant(P<0.05).After 8 weeks of treatment,the maximum maximal flow rate(Qmax),mean voided volume(Vcomp) and maximum urethral pressure(MUP) of the two groups were higher than those before treatment.The post void residual ruine(RVU) level after treatment was lower than that before treatment.Compared with the control group,the observation group had higher Qmax,Vcomp,MUP levels and lower RVU levels,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group(9.30%) and the control group(0.00%)(P>0.05).Conclusion Tolterodine is effective in the treatment of patients with rectal cancer postoperative dysuria,which is helpful to reduce the dysuria,improve the urodynamic indexes and symptoms of overactive bladder,and has fewer adverse reactions.