绝经后女性冠心病患者心功能及血浆雌二醇、NT-proBNP水平研究

目的探讨绝经后女性冠心病患者心功能及血浆雌二醇、N-末端脑钠肽前体(NT-pro BNP)水平。方法选择2017年10月-2018年10月的绝经后女性130例,分为研究组(65例冠心病患者)和对照组(65例无冠心病女性)。比较两组心功能指标及血浆雌二醇、NT-pro BNP水平,比较不同冠脉病变支数、位置的冠心病患者心功能指标及血浆雌二醇、NT-pro BNP水平。结果两组左室射血分数(LVEF)、左室舒张末压(LVEDP)、左室舒张末期内径(LVEDd)、血浆雌二醇及NTpro BNP水平比较差异有统计学意义(P<0. 05)。不同冠脉病变支数、位置的冠心病患者LVEF、LVEDd、LVEDP、血浆雌二醇及NT-pro BNP水平比较差异有统计学意义(P<0. 05)。结论绝经后女性冠心病的发生对患者心功能有一定影响,患者血浆NTpro BNP水平升高,血浆雌二醇水平降低。血浆雌二醇可改善血管内皮功能,保护心血管,在一定程度上延缓病情发展,提高血浆雌二醇水平能发挥预防和延缓病情发展的作用,具有重要的临床意义。

Study on cardiac function and plasma estradiol and NT-proBNP levels in postmenopausal women with coronary heart disease

Objective To explore cardiac function and plasma estradiol and N-terminal pro-brain natriuretic peptide( NT-pro BNP)levels in postmenopausal women with coronary heart disease. Methods A total of 130 postmenopausal women were selected and divided into study group( 65 patients with coronary heart disease) and control group( 65 women without coronary heart disease) from October 2017 to October 2018. Cardiac function indicators,plasma estradiol and NT-pro BNP levels in the two groups were compared;cardiac function indicators,plasma estradiol and NT-pro BNP levels in coronary heart disease patients with different lesion vessel numbers and locations were compared. Results There were statistically significant differences in left ventricular ejection fraction( LVEF),left ventricular end-diastolic pressure( LVEDP),left ventricular end diastolic diameter( LVEDd),plasma estradiol and NT-pro BNP levels between the two groups( P<0. 05). There were statistically significant differences in LVEF,LVEDd,LVEDP,plasma estradiol and NT-pro BNP levels among coronary heart disease patients with different lesion vessel numbers and locations( P<0. 05). Conclusion Coronary heart disease has a certain impact on cardiac function of postmenopausal women,plasma NT-pro BNP level increases,while plasma estradiol level decreases. Plasma estradiol can improve endovascular function,protect cardiovascular function,delay the aggravation of coronary heart disease to a certain extent,increasing plasma estradiol level can prevent and delay the aggravation of coronary heart disease,which has important clinical significance.