哮喘患者病程严重程度与嗜酸性粒细胞、中性粒细胞、血浆硫化氢的相关性分析

目的 探讨哮喘患者病程严重程度与嗜酸性粒细胞、中性粒细胞、血浆硫化氢(H2S)的相关性。方法 选取我院2017年4月～2019年3月收治的急性发作期哮喘患者70例作为研究组,根据疾病诊断指南进行分度,轻度、中度和重度患者分别18、23、29例,选取同期进行体检的健康人70例作为对照组,所有受试对象均进行诱导痰计数,计算嗜酸性粒细胞、中性粒细胞占比,并抽取血液测定血浆H2S水平,比较对照组和研究组以及研究组不同严重程度患者的诱导痰嗜酸性粒细胞和中性粒细胞占比及血浆H2S水平,对三个指标进行相关性分析。结果研究组患者诱导痰嗜酸性粒细胞和中性粒细胞占比显著高于对照组,血浆H2S水平显著低于对照组;随着疾病程度加重,哮喘患者诱导痰嗜酸性粒细胞和中性粒细胞占比逐渐升高,而血浆H2S水平逐渐降低;哮喘患者血浆H2S与诱导痰嗜酸性粒细胞、中性粒细胞占比之间呈负相关;血浆H2S水平和疾病严重程度呈负相关,诱导痰嗜酸性粒细胞、中性粒细胞占比和疾病严重程度呈正相关。以上差异有统计学意义(P0.05)。结论 哮喘患者诱导痰嗜酸性粒细胞、中性粒细胞占比升高,血浆H2S水平降低,随着病程的逐渐加重,哮喘患者嗜酸性粒细胞、中性粒细胞占比会逐渐升高,血浆H2S水平将逐渐降低。

Analysis on the correlation between severity of asthma disease course and eosinophils,neutrophils and plasma hydrogen sulfide in the patients with asthma

Objective To investigate the correlation between the severity of asthma disease course and eosinophils,neutrophils and plasma hydrogen sulfide(H2S) in the patients with asthma.Methods 70 patients with acute attack of asthma who were admitted to our hospital from April 2017 to March 2019 were selected as study group.According to the disease diagnosis guide,the patients were divided into mild,moderate,and severe conditions,with 18,23,and 29 patients,respectively.70 healthy people who were selected for physical examination at the same time were selected as the control group.All subjects were given induced sputum counts to calculate the ratios of eosinophils and neutrophils,and the blood was collected to measure plasma H2S levels.The ratios of induced sputum eosinophils and neutrophils and plasma H2S levels were compared between the control group and between patients with different disease severity in the study group.Correlation analysis was performed on the three indices.Results The ratio of eosinophils and neutrophils induced by sputum in the study group was significantly higher than that in the control group,and the plasma H2S level was significantly lower than that in the control group; as the degree of disease worsened,the ratio of eosinophils and neutrophils induced by sputum in the patients with asthma was gradually increased,while the level of plasma H2S was gradually decreased;there was a negative correlation between plasma H2S level and the ratio of eosinophils and neutrophils induced by sputum in the patients with asthma; there was a negative correlation between plasma H2S level and disease severity.There was a positive correlation between the ratio of eosinophils and neutrophils induced by sputum and disease severity(P<0.05 for all).Conclusion The ratio of eosinophils and neutrophils induced by sputum in the patients with asthma is increased,and plasma H2S level is decreased.As the course of disease worsens,the ratio of eosinophils and neutrophils in the patients with asthma will gradually increase,and plasma H2S level will gradually decrease.