曲美他嗪对急性心肌梗死患者介入治疗后心功能及左心室重构的疗效观察

目的 探讨曲美他嗪对急性心肌梗死患者介入治疗后心功能及左心室重构的疗效。方法 选择2018年1月～2019年1月我院收治的ST段抬高型心肌梗死经皮冠状动脉介入术(PCI)治疗患者80例,随机分为观察组和对照组,每组40例。对照组PCI术后予他汀类、硝酸酯类、肠溶阿司匹林及β受体阻滞剂等常规药物进行治疗;观察组在对照组的基础上予曲美他嗪口服20 mg/次,3次/d,连续治疗3个月。治疗后对比分析两组患者的心功能及左心室重构各项指标。结果 治疗前观察组和对照组患者的SV、CO、LVEF指标比较,差异无统计学意义(P0.05);治疗后观察组患者的SV、CO、LVEF指标分别显著高于对照组,组间比较差异有统计学意义(P0.05)。治疗前观察组和对照组患者的LVEDV、LVESV、LVDd、LVDs指标比较,差异无统计学意义(P0.05);治疗后观察组患者的LVEDV、LVESV、LVDd、LVDs指标分别显著低于对照组,组间比较差异有统计学意义(P0.05)。结论 曲美他嗪用于急性心肌梗死患者介入治疗后可以明显改善心功能及左心室重构,疗效确切,值得广泛推广和应用。

Effect of trimetazidine on cardiac function and left ventricular remodeling after interventional therapy in patients with acute myocardial infarction

Objective To investigate the effect of trimetazidine on cardiac function and left ventricular remodeling after interventional therapy in patients with acute myocardial infarction.Methods Eighty patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention(PCI) were enrolled in our hospital from January 2018 to January 2019.All patients were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with conventional drugs such as statins,nitrates,enteric-coated aspirin and beta-blockers after PCI.The observation group received oral trimetazidine 20 mg/times,3 times/d based on the treatment of the control group,with continuous treatment for 3 months.After treatment,the indexes of cardiac function and left ventricular remodeling were compared between the two groups.Results Before treatment,the SV,CO and LVEF indexes between the observation group and the control group were not significantly different(P>0.05).After treatment,the SV,CO,and LVEF indexes of the observation group were significantly higher than those of the control group.The differences in SV,CO,and LVEF between the two groups were statistically significant(P<0.05).Before treatment,the LVEDV,LVESV,LVDd,and LVDs indexes between the observation group and the control group were not significantly different(P>0.05).After treatment,the LVEDV,LVESV,LVDd,and LVDs indexes in the observation group were significantly lower than those in the control group.The differences in LVEDV,LVESV,LVDd,and LVDs between the two groups were statistically significant(P<0.05).Conclusion Trimetazidine can significantly improve cardiac function and left ventricular remodeling after interventional therapy in patients with acute myocardial infarction.It has definite curative effect and is worthy of widespread application and application.