| 细胞凋亡在骨折愈合中的作用 |
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| 引用本文： | 司晓辉,金岩,杨连甲. 细胞凋亡在骨折愈合中的作用[J]. 上海口腔医学, 2001, 10(2): 132-134 |
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| 作者姓名： | 司晓辉 金岩 杨连甲 |
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| 作者单位： | 1. 上海第二医科大学附属第九人民医院口腔医学研究所,
2. 第四军医大学口腔医学院病理科, |
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| 摘 要： | 目的 探讨骨折愈合过程中细胞凋亡的发生及意义。方法 建立颌骨骨折模型,利用末脱氧核苷酸酶（TdT)介导的dUTP－X切口末端标记（TUNEL）法,原位观察骨折愈合不同时期细胞凋亡的发生情况。结果 在整个愈合过程中,均可见凋亡细胞,而膜内骨化膜(第5d）和软骨形成期（第11d) 凋亡细胞明显增多。结论 骨折愈合过程伴随凋亡的发生,通过凋亡机控制控制细胞的数量和清除无用的细胞,以利于组织的正常修复。
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| 关 键 词： | 凋亡 骨折愈合 TUNEL |
| 文章编号： | 1006-7248(2001)02-0132-03 |
| 修稿时间： | 1999-08-20 |
The Effects of Apoptosis during Fracture Healing |
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| SI Xiao hui ,JIN Yan ,YANG Lian jia .. The Effects of Apoptosis during Fracture Healing[J]. Shanghai journal of stomatology, 2001, 10(2): 132-134 |
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| Authors: | SI Xiao hui JIN Yan YANG Lian jia . |
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| Affiliation: | Research Institute of Stomatology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China. |
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| Abstract: | Objective To elucidate the occurrence and significance of apoptosis during fracture healing of the mandible. Methods An experimental model of fracture was established to detect apoptosis in the different stages of healing by TdT mediated dUTP nick end labeling (TUNEL) method. Results Apoptosis was observed in the whole healing process. The apoptotic cells markedly increased in the stage of intramembranous bone formation (5d) and chondrogenesis (11d). Conclusions Apoptosis is involved in fracture healing. The number of cells was controlled and the useless cells were eliminated by means of apoptosis. This process is helpful to the healing of tissues. [ |
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| Keywords: | Apoptosis Fracture Healing TUNEL |
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