| 白藜芦醇的雌激素样作用研究 |
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| 引用本文： | 刘兆平,于波,李文仙,孙静,黄建,霍军生,刘长兴.白藜芦醇的雌激素样作用研究[J].卫生研究,2002,31(3):188-190. |
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| 作者姓名： | 刘兆平 于波 李文仙 孙静 黄建 霍军生 刘长兴 |
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| 作者单位： | 1. 中国预防医学科学院营养与食品卫生研究所,北京,100050
2. 龙兴生物工程研究所 |
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| 摘 要： | 为研究白藜芦醇在体内的雌激素样作用 ,给刚断乳小鼠分别皮下注射和灌胃不同剂量的白藜芦醇 ,观察该物质对子宫和阴道的影响。结果显示 ,2 0mg kg .BW的白藜芦醇可明显促进未成熟小鼠阴道开口 (P <0 0 5 )和阴道上皮角化 ,显著增加子宫重量及其系数 (P <0 0 5 ,P <0 0 1) ,并可使子宫内膜柱状上皮增厚或腺体增生。结果表明白藜芦醇在体内具有雌激素样作用。而口服白藜芦醇的雌激素活性明显弱于皮下注射
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| 关 键 词： | 白藜芦醇 雌激素样作用 小鼠 |
| 文章编号： | 1000-8020(2002)03-0188-03 |
| 修稿时间： | 2001年9月25日 |
Estrogenicity of trans-resveratrol in immature mice in vivo |
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| Liu Zhaoping,Yu Bo,Li Wenxian,Sun Jing,et al..Estrogenicity of trans-resveratrol in immature mice in vivo[J].Journal of Hygiene Research,2002,31(3):188-190. |
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| Authors: | Liu Zhaoping Yu Bo Li Wenxian Sun Jing |
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| Institution: | Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China. |
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| Abstract: | To investigate the estrogenicity of trans resveratrol in vivo, different doses of trans resveratrol were administered orally (ig.) or subcutaneously (sc.) to the weanling mice for 4 d. The results showed that 2 0 mg/kg.b.w of trans transveratrol (ig or sc) could shorten vaginal opening latency periods ( P <0 05) and enhance keratinization of vaginal epithelium dramatically, increase uterine wet weights and uterine body weight ratios significantly ( P <0 05, P <0 01). Additionally, trans transveratrol could thicken the columnar epithelial cells or increase the numbers of glands in uterine in immature mice. It was concluded that trans transveratrol could appear estrogenic actions in vivo. Moreover, its activity via subcutaneous administration was higher than that via oral administration. |
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| Keywords: | trans resveratrol estrogenicity mice |
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