蛋白质组学在眼底病研究中的应用

蛋白质组学是从整体的角度分析动态变化的蛋白质组成、表达水平和修饰状态，了解蛋白质之间相互作用的学科，开辟了研究蛋白质功能与细胞生命活动规律的新领域。通过对生理及病理状态下蛋白质的分析比较，蛋白质组学研究在许多疾病的早期诊断、药物治疗靶点的研究等方面取得了一定进展，也逐渐被应用于眼部疾病包括眼底疾病的研究，如年龄相关性黄斑变性（AMD）、糖尿病视网膜病变（DR）、增生性玻璃体视网膜病变（PVR）、视网膜变性、孔源性视网膜脱离（RRD）等。蛋白质组学在眼底病研究中的应用尚处于起步阶段，就蛋白质组学在眼底病尤其是高致盲性眼病研究中的应用进行综述。

Application of proteomic in the research of vitreoretinopathy

Proteomic studies encompass the analysis of expression levels of proteins as well as protein interactions and post-translational modification which affect protein function from the overall and dynamic point of view.By the comparison and analysis of proteome between physiology and pathology,we can find the specific protein molecule on certain diseases,and it provide the identification markers of the diseases for early diagnosis,and point out the molecule target of the new drugs.At present,proteomic study has been applied in the diagnosis and treatment of multiple fundus diseases,such as age-related macular degeneration,diabetic retinopathy,proliferative vitreoretinopathy,retinal degeneration and rhegmatogenous retinal detachment.However,these researches are only at primary stage.Now,this article reviews the proteomics advancements in vitreous and retinopathy with the focus on the causingblindness diseases.