Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents |
| |
| Authors: | Rajesh Sharma Ganesh Prasad Misra Jitendra Sainy Subhash Chandra Chaturvedi |
| |
| Affiliation: | (1) School of Pharmacy, Devi Ahilya Vishwavidyalaya, Thakshyasila Campus, Khandwa Road, Indore, Madhya Pradesh, 452 001, India;(2) College of Pharmacy, IPS Academy, A.B. Road, Rau, Indore, Madhya Pradesh, 452 001, India |
| |
| Abstract: | A new series of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for central nervous system activity. Compounds 1, 5, 7, 10, 14 exhibited significant antidepressant, anxiolytic and anticonvulsant activity in comparison to the reference drugs. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
