缺氧后肌阵挛2例报道并文献复习

目的探讨缺氧后肌阵挛(posthypoxic myoclonus,PHM)的发病机制、临床表现、神经电生理、治疗及预后。方法收集2例PHM患者临床资料,分析其临床表现、脑电图特征及治疗及预后,并复习文献。结果 2例患者为心肺复苏后病人,表现反复发作短暂而快速的肢体抽动,脑电图显示无癫活动,常规抗癫治疗效果不肯定。结论 PHM临床表现与肌阵挛癫相似,电生理检查无特异性,拉莫三嗪、左乙拉西坦等药物可试用于临床。

Posthypoxic myoclonus:Report of 2 cases and review of literature

Objective To investigate the pathogenesis,clinical manifestations,nerve electrophysiology,treatment and prognosis of posthypoxic myoclonus(PHM).Methods Clinical data of 2 PHM patients were collected to analyze their clinical information,electroencephalography features,treatments and prognosis,and corresponding literatures were reviewed.Results The two patients were cardiorespiratory resuscitation patients,characterized by recurrent seizures temporal and Volant limbs tic,electroencephalography didn’t demonstrate epilepsia activity,after rout treatments of anti-epileptic,the results weren’t confirmed.Conclusion The clinical manifestations of PHM are similar to myoclonic epilepsy,the examinations of electrophysiology are not specific.AEDS such as lamotrigine,levetiracetam may be tried to treat PHM.