| 乳胞素对SD大鼠脑出血模型神经新生的影响及机制 |
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| 引用本文： | 陈勇,高林,耿利娇,贺维亚.乳胞素对SD大鼠脑出血模型神经新生的影响及机制[J].中国实用神经疾病杂志,2011,14(3):10-12. |
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| 作者姓名： | 陈勇 高林 耿利娇 贺维亚 |
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| 作者单位： | 河南大学淮河医院,开封,475000 |
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| 摘 要： | 目的 探讨UPS抑制剂乳胞素(lactacystin)对SD大鼠脑出血模型神经新生的影响及机制.方法 采用Ⅶ型胶原酶诱导SD大鼠脑出血模型,分为对照组(A组),乳胞素处理组(B组),每组各20只;造模成功后第1～7天B组腹腔注射1 mg/(kg·d)的乳胞素,A组腹腔注射等剂量生理盐水.第3周断头处死SD大鼠,以组织化...
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| 关 键 词： | 乳胞素 泛素-蛋白酶体系统 转录因子-核因子-κB 脑出血模型 |
Effect of lactacystin on nerve newborn ability of intracerebral hemorrhage model and its mechanism |
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| Institution: | Chen Yong,Gao Lin,Geng Lijiao,et al.Department of Neurology,the Affiliated Huaihe Hospital of Henan University,Kaifeng 475000,China |
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| Abstract: | ObjectiveTo investigate the effect of lactacystin on nerve newborn ability of Sprague-Dawley rat intracerebral hemorrhage model and its mechanism.MethodsMale SD rats were divided into control group(group A),lactacystin group(group B),and each group of 20 rats.In the first 1～7 days,group B was intraperitoneally injected 1 mg/(kg·d) lactacystin,groups A was intraperitoneally injected equal dose of normal saline.In the third week,all rats were decapitated,UPS and NF-κB content in striatum was measured by using spectrophotometer tyrosine.Brdu-positive neurons in striatum were identified by immunohistochemistry.ResultsCompared with group A,UPS and NF-κB content in striatum of group B decreased significantly(P<0.01),in damaged side of the striatum Brdu-positive cell counts increased(P<0.01).ConclusionNerve newborn ability of Sprague-Dawley rat intracerebral hemorrhage model was promoted by lactacystin,its mechanism may be related to suppress the UPS,regulative NF-κB content,reduce the neuron to apoptosis,and thus promote the neuron newborning. |
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| Keywords: | Lactacystin UPS NF-κB Intracerebral hemorrhage model |
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