| 银杏叶提取物对大鼠脑缺血再灌注后GFAP和细胞凋亡的影响 |
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| 引用本文： | 段周芳,王金兰,娄季宇,刘义峰,李青,何美霞. 银杏叶提取物对大鼠脑缺血再灌注后GFAP和细胞凋亡的影响[J]. 中国实用神经疾病杂志, 2011, 14(3): 25-27 |
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| 作者姓名： | 段周芳 王金兰 娄季宇 刘义峰 李青 何美霞 |
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| 作者单位： | 1. 郑州大学第二附属医院神经内科,郑州,450014
2. 河南省医药科学研究院,郑州,450052 |
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| 摘 要： | 目的 研究银杏叶提取物(EGb761)对大鼠局灶性脑缺血再灌注后神经细胞凋亡和星形胶质细胞表达的变化.方法 雄性SD大鼠随机分为假手术组、单纯缺血组、EGb761干预组,线栓法建立大脑中动脉缺血再灌注模型(MCAO),原位末端标记(TUNEL)法观察神经细胞的凋亡情况,免疫组化法观测星形胶质细胞的表达.结果 与单纯缺血...
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| 关 键 词： | 脑缺血再灌注 大鼠 星形胶质细胞 细胞凋亡 EGb761 |
Effect of Ginkgo biloba on the expression of GFAP and the apoptosis cells after the cerebral ischemia and reperfusion in rats |
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| Affiliation: | Duan Zhoufang,Wang Jinlan,Lou Jiyu,et al.Department of Neurology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China |
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| Abstract: | ObjectiveTo investigate the effects of Ginkgo biloba extract on the neuronal apoptosis and the expression of GFAP in rats after cerebral ischemia-reperfusion.MethodsMale SD rats were randomly divided into the sham-operated group,control group and EGb761 treatment group,the middle cerebral artery ischemia-reperfusion model(MCAO) was established using line bolt method.In situ end-labeling(TUNEL) method was used to observe nerve cell apoptosis,the expressions of GFAP changes were detected by immunohistochemistry after cerebral ischemia-reperfusion.ResultsCompared with the hypoperfusion group,the number of GFAP,the apoptosis cells were decreased significantly in the EGb761 group,the difference was statistically significant(P<0.05).ConclusionGinkgo biloba extract could restrain the excessive activation of astrocytes and reduce the nerve cell apoptosis.It plays a nerve protective effect. |
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| Keywords: | EGb761 |
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