丁苯酞软胶囊治疗急性脑梗死临床观察

目的观察丁苯酞软胶囊治疗急性脑梗死的临床疗效及安全性。方法 80例急性脑梗死患者随机分为对照组和丁苯酞治疗组,对照组给予拜阿司匹林、依达拉奉等治疗,丁苯酞治疗组在对照组的基础上加用丁苯酞软胶囊。在入院第1d、第7 d、第14 d、21 d及28 d进行NIHSS评分及日常生活能力评分,在第1天第14天及第28天检测肝功、肾功,血凝常规。结果 2组14 d、21 d、28 d的NIHSS评分、Barthel指数评分均较治疗前明显好转,观察组优于对照组,差异有显著性(P<0.01);而2组的血凝常规比较差异无显著性。结论丁苯酞治疗急性脑梗死能有效改善神经功能缺损。而相对安全,对肝、肾功、凝血功能无明显影响。可作为急性期脑梗死治疗安全有效的选择。

Effect of dl-3n-butylphthalide soft capsule in acwe cerebral infarction

Objective To observe the effect of DI-3n-Butylphthode soft capsule in acute cerebral infarction patients.Methods Eighty cases of patients were chosen and dived randomly into two groups.Forty-three cases of patients in treatment group were given conventional drug combined with orally 200 mg of dl-3n-butylphthalide soft capsule,tid,for 20 days.Thirty-seven cases of patients in control group were given conventional drug treatment.The both groups were evaluated by National Institutes of Health Stroke Scale(NIHSS) and Barthel Index(BI).Results The results of NIHSS and Barthel index in study group between control group had statistical difference.Conclusion dl-3n-butylphthalide soft capsule is safe,and has great effect on acute cerebral infarction.