体素内不相干运动成像用于脑胶质瘤分级:Meta分析

目的 以Meta分析方法评价体素内不相干运动(IVIM)成像参数真性扩散系数(D)、假性扩散系数(D*)及灌注分数(f)鉴别高、低级别脑胶质瘤的价值.方法 检索EMbase、PubMed、中国生物医学文献数据库、中国知网、万方医学网和维普数据库中自建库至2020年2月关于IVIM各参数鉴别诊断高、低级别脑胶质瘤的相关文...

Intravoxel incoherent motion imaging in grading of brain gliomas: Meta-analysis

Objective To observe the diagnostic value of intravoxel incoherent motion (IVIM) imaging parameters true diffusion coefficient (D), pseudo-diffusion coefficient (D^*) and perfusion fraction (f) in differentiating high and low grade brain gliomas with meta-analysis. Methods Literature concerning IVIM parameters for differential diagnosis of high and low grade brain gliomas were searched in the EMbase, PubMed, CBMdisc, CNKI, Wanfang Med Online and VIP databases from the time of database establishment to February 2020, and then screened according to inclusion and exclusion criteria. Meta-analysis was performed using Metadisc 1.4 and STATA 15.1 software. Results Totally 13 articles (8 in Chinese and 5 in English) and 590 cases of brain gliomas were enrolled, including 240 cases of low grade and 350 cases of high grade brain gliomas. D, D^* and f had no obvious threshold effect in differentiating high and low grade brain gliomas (r=0.609, -0.387, -0.091; P=0.074, 0.214, 0.790). According to the heterogeneity test, there was no heterogeneity among 13 articles, and the fixed-effect model was used for analysis. The summary sensitivity of D, D^* and f for differential diagnosis of high and low grade brain gliomas was 0.86 (95%CI[0.81, 0.89]), 0.81 (95%CI[0.76, 0.85]) and 0.80 (95%CI[0.75, 0.84]), respectively, and the summary specificity was 0.74 (95%CI[0.67, 0.80]), 0.75 (95%CI[0.69, 0.81]) and 0.80 (95%CI[0.74, 0.85]), respectively. The summary receiver operating characteristics (SROC) curve showed that the area under the curve (AUC) of D, D^* and f was 0.898, 0.860 and 0.874, respectively. Conclusion IVIM parameters D, D^* and f values had certain clinical application value for differential diagnosis of high and low grade of brain gliomas, and their diagnostic efficacies were similar.