首页 | 本学科首页   官方微博 | 高级检索  
     


Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-β) in leprosy lesions
Authors:Khanolkar-Young  Snowdon  Lockwood
Abstract:Inducible nitric oxide synthase (iNOS) and TGF-β were localized by immunocytochemistry in skin lesions from patients across the leprosy spectrum, and from patients undergoing reversal reaction. iNOS expression was highest at the tuberculoid pole of the spectrum, and increased during reversal reaction. TGF-β was observed throughout the leprosy spectrum, but was highest at the lepromatous pole. Levels of TGF-β decreased during reversal reaction. Reduced levels of TGF-β may contribute to unregulated inflammatory responses during reactional episodes.
Keywords:leprosy iNOS  transforming growth factor-beta  immunocytochemistry
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号