中枢神经系统感染患儿脑脊液中肿瘤坏死因子与白细胞介素-8变化的研究

目的 :探讨肿瘤坏死因子 (TNF)、白细胞介素 - 8(IL - 8)在小儿中枢神经系统感染性疾病中的意义。方法 :采用放射免疫方法 (RIA )对中枢神经系统感染的 40例患儿分别进行脑脊液中 TNF、IL - 8含量的检测 ,并与无中枢神经系统感染的 2 0例患儿进行比较。结果 :在疾病的急性期 ,细菌性脑膜炎患儿脑脊液中 TNF、IL - 8含量均显著高于对照组和病毒性脑炎组 ,P<0 .0 1。恢复期 ,菌脑组 TNF、IL - 8含量较治疗前明显下降 ,P<0 .0 1。结论 :脑脊液中TNF、IL - 8含量的检测有助于细菌性与非细菌性脑膜炎的诊断、鉴别诊断 ,并且还有助于细菌性脑膜炎的疗效观察。

The clinical significance of cerebrospinal fluid tumor necrosis factor-αand interleukin-8 levels in children with central nervous system infection

Objective:To evaluate the clinical significance of CSF tumor necrosis factor-α (TNF) and interleukin-8(IL-8) levels in children with central nervous system(CNS) infection.Methods:The RIA method was used to analyze the level of TNF and IL-8 in CSF of 40 children with CNS infection and 20 children with no CNS infection.Results:The level of TNF and IL-8 in the CSF in CNS bacterial infectons was higher than those in the controlled group and viral groupP<0.01.After treatment the level of TNF and IL-8 in the CSF in bacterial group was markedly decrease than before P<0.01.Conclusion:TNF and IL-8 measurement of the CSF may be useful for differential diagnosis of CNS bacterial infection and no bacterial infection and may be also useful for therapeutic observation of CNS bacterial infection.