The predictive value of P300-amplitudes in the course of schizophrenic disorders |
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Authors: | W. K. Strik Th. Dierks H. Kulke K. Maurer A. Fallgatter |
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Affiliation: | (1) Present address: Department of Psychiatry, University of Würzburg, Germany;(2) Department of Psychiatry, University of Frankfurt/M., Germany;(3) LKH Weinsberg, Germany |
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Abstract: | Summary Auditory P300-amplitudes have been found to be correlated with the social functioning and with the impairment in daily life by negative symptoms in cross-sectional studies. In this prospective longitudinal study, the correlation of auditory P300-amplitudes registrated at the index examination was investigated with the clinical outcome after an average of 2.4 years. Based on previous studies, only schizophrenic patients who were in a stabilized residual state were included in the study. Reference-independent P300-parameters of the index examination were correlated with axis V of DSM-III-R (GAP), with the Brief Psychiatric Rating Scale (BPRS) and with the Scale for Assessment of Negative Symptoms (SANS) assessed at the follow-up examination. The correlation of index P300-amplitude with social functioning at follow-up was significant. No correlations of index P300 with the current symptomatology at follow-up, as expressed by BPRS and SANS was found, however. The results indicate a predictive value of the P300-amplitude on the clinical outcome in terms of social functioning of schizophrenic patients. |
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Keywords: | Evoked potentials schizophrenia P300 prognosis |
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