乳腺癌病人血D-二聚体水平与临床病理学特征的相关性

目的探讨乳腺癌病人血D-二聚体(D-D)水平与其临床病理学特征的相关性，以期为临床对乳腺癌病人的诊断、病情进展和预后评估提供临床证据。方法采用随机数字表法选取54例乳腺癌病人作为恶性肿瘤组，同法随机选取同期乳腺良性病变54例作为良性病变组。所有入组病人于入院时抽取静脉血检测血D-D；乳腺癌标本雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体(Her-2)和Ki-67表达情况来源于医院病理诊断报告。分析恶性肿瘤组和良性病变组病人血D-D水平的差异，并研究恶性肿瘤组乳腺癌病人血D-D水平与其临床病理特征的关系。结果恶性肿瘤组D-D水平高于良性病变组(P < 0.01)。有淋巴结转移者D-D水平高于无转移者(P < 0.05)；TNM Ⅰ期与Ⅱ期D-D水平差异无统计学意义(P>0.05)，Ⅲ期D-D水平高于Ⅰ期和Ⅱ期(P < 0.05)；Ki-67高表达D-D值高于低表达(P < 0.05)，但低表达与中表达、中表达与高表达比较差异无统计学意义(P>0.05)。ER、PR、Her-2不同表达情况的D-D比较差异无统计学意义(P>0.05)。结论D-D水平升高与乳腺癌TNM分期、淋巴结转移、Ki-67表达相关, 提示检测乳腺癌病人D-D水平可作为诊断、病情与预后评估的辅助指标之一。

Correlation between serum D-dimer level and clinicopathological features in breast cancer patients

ObjectiveTo explore the correlation between blood D-dimer (D-D) level and clinicopathological characteristics of breast cancer patients, in order to provide possible clinical evidence for the diagnosis, disease progression and prognosis evaluation of breast cancer patients.MethodsFifty-four breast cancer patients were selected as the malignant tumor group by random number table method, and 54 patients with benign breast lesions during the same period were randomly selected as the benign lesion group.All patients were drawn with venous blood at the time of admission to the hospital to detect the level of D-D in the blood.The expression of ER, PR, Her-2 and Ki-67 in breast cancer specimens was obtained from the hospital pathological diagnosis report.The differences in the level of D-D between the malignant tumor group and the benign lesion group were analyzed, and the relationship between the level of D-D and their clinicopathological characteristics of breast cancer patients in malignant tumor group were studied.ResultsThe level of D-D in the malignant tumor group was significantly higher than that in the benign lesion group(P < 0.01).The D-D level in patients with lymph node metastasis was higher than that without metastasis (P < 0.05).There was no significant difference between the D-D level of the patients TNM stage Ⅰ and stage Ⅱ(P>0.05);stage Ⅲ was higher than stage Ⅰ and stage Ⅱ(P < 0.05).Ki-67 high-expression D-D values were higher than low-expression (P < 0.05), but there was no difference between low-expression and medium-expression, medium-expression and high-expression(P>0.05).There was no significant difference in the D-D level of different expressions of ER, PR and Her-2 in immunohistochemistry (P>0.05).ConclusionsThe elevated level of D-D is associated with breast cancer TNM stage, lymph node metastasis and Ki-67 expression.It is suggested that the detection of D-D level in breast cancer patients be used as one of the auxiliary indicators for diagnosis, condition and prognosis evaluation.