高通量血液透析和血液透析滤过对慢性肾衰竭尿毒症病人体内毒素清除效果对比分析

目的分析慢性肾衰竭尿毒症病人进行高通量血液透析(HFHD)和血液透析滤过(HDF)病人体内毒素清除效果。方法慢性肾衰竭尿毒症病人122例作为研究对象, 结合病人首次接受透析的时间排序后进行分组, 单号为对照组, 双号为观察组, 对照组病人采用HDF治疗, 观察组病人采用HFHD治疗, 对2组病人体内毒素清除效果进行对比分析, 观察2种方法的应用效果。结果2组病人小分子毒素指标清除率差异均无统计学意义(P>0.05);2组病人的慢性肾衰竭性尿毒症病人在透析后其大、中分子毒素均有较好改善(P < 0.01), 观察组改善情况明显优于对照组(P < 0.01);观察组尿素的清除时间、标准蛋白质分解代谢率指标与对照组差异均无统计学意义(P>0.05);观察组透析后并发症发生率明显低于对照组(P < 0.01)。结论在慢性肾衰竭尿毒症病人的毒素分子清除中HFHD治疗对较大分子有更好的透析效果, 同时降低并发症发生率, 值得在临床应用。

Comparative analysis of toxin clearance between hemodiafiltration and high-flux hemodialysis in uremia patients with chronic renal failure

ObjectiveTo compare the effects of toxin clearance between high-flux hemodialysis(HFHD) and hemodiafiltration(HDF) in uremia patients with chronic renal failure.MethodsA total of uremia 122 patients with chronic renal failure were investigated.The patients were divided into the control group and observation group according to the time of the first dialysis.The observation group and control group were treated with HDF and HFHD, respectively.The toxin clearance effects were compared between two groups, and the application effects of two methods were analyzed.ResultsThere was no statistical significance in the clearance rate of small molecule toxins between two groups(P>0.05).The large and medium molecule toxins clearance in two groups were improved after dialysis(P < 0.01), and the improvement in observation group was significantly better than that in control group(P < 0.01).There was no statistical significance in urea clearance time and standard protein catabolic rate index between two groups(P>0.05).The incidence rate of post-dialysis complications in observation group was significantly lower than those in control group(P < 0.01).ConclusionsHFHD on clearance of large molecule toxins in uremia patients with chronic renal failure has better effects, can reduce the incidence rate of complications, and is worthy of clinical application.