分级步行运动方案对肺癌化疗病人癌因性疲乏的影响

目的研究分级步行运动方案对肺癌化疗病人癌因性疲乏(CRF)的影响。方法选取90例肺癌化疗病人为研究对象，随机分成干预组和对照组，各45例，对照组采用化疗常规指导，干预组采用分级步行运动方案进行步行运动指导，共干预8周。比较2组步行运动量、CRF程度分布、癌因性疲乏量表(CFS)得分和6 min步行试验(6MWT)步行距离。结果干预组步行运动量为(8 295±912)步/天，对照组步行运动量为(31 02±1 113)步/天，差异有统计学意义(P < 0.01)。2组化疗前和干预4周CRF程度分布差异均无统计学意义(P>0.05)；干预8周和干预后3个月，干预组CRF程度分布均明显优于对照组(P < 0.01)。2组化疗前和干预4周CFS得分差异均无统计学意义(P>0.05)；干预8周和干预后3个月，干预组CFS得分明显低于对照组(P < 0.01)。干预组CFS得分在干预后逐渐降低(P < 0.01)，对照组CFS得分在干预后逐渐升高(P < 0.01)。2组化疗前和干预4周6MWT步行距离差异均无统计学意义(P>0.05)；干预8周和干预后3个月，干预组6MWT步行距离均大于对照组(P < 0.05和P < 0.01)。干预组化疗前至干预8周，6MWT步行距离变化不明显(P>0.05)，但干预后3个月6MWT步行距离均高于干预前、干预4周和干预8周(P < 0.05)。对照组在干预过程中6MWT步行距离变化呈下降趋势(P < 0.01)。结论分级步行运动方案能减轻肺癌化疗病人CRF，有效提高干预后6MWT步行距离，干预8周初显成效。

Effect of graded walking exercise program on cancer-related fatigue in patients with lung cancer undergoing chemotherapy

ObjectiveTo study the effect of graded walking exercise program on cancer-related fatigue(CRF) in patients with lung cancer undergoing chemotherapy.MethodsA total of 90 patients with lung cancer undergoing chemotherapy were selected as the research subjects and randomly divided into the intervention group and control group, with 45 cases in each group.The control group was treated with routine chemotherapy guidance, and the intervention group was treated with graded walking exercise program for a total of 8 weeks of intervention.The amount of walking exercise, CRF degree distribution, cancer-related fatigue scale(CFS) score and walking distance of 6-minute walking test(6MWT) were compared between the two groups.ResultsThe amount of walking exercise in the intervention group was(8 295±912) steps/day, which in the control group was(3 102±1 113) steps/day, and the difference of which was statistically significant(P < 0.01).There was no significant difference in CRF degree distribution between the two groups before chemotherapy and 4 weeks after intervention(P>0.05), and the CRF degree distribution in the intervention group was significantly better than that in the control group at 8 weeks after intervention and 3 months after intervention(P < 0.01).There was no significant difference in CFS scores between the two groups before chemotherapy and 4 weeks after intervention(P>0.05), and the CFS score in the intervention group was significantly lower than that in the control group at 8 weeks after intervention and 3 months after intervention(P < 0.01).The CFS score in the intervention group gradually decreased after the intervention(P < 0.01), and which in the control group gradually increased after the intervention(P < 0.01).There was no significant difference in 6MWT walking distance between the two groups before chemotherapy and 4 weeks after intervention(P>0.05), and the 6MWT walking distance in the intervention group at 8 weeks after intervention and 3 months after intervention was greater than that in the control group(P < 0.05 and P < 0.01).The 6MWT walking distance in the intervention group did not change significantly from pre-chemotherapy to the eighth week of intervention(P>0.05), but the 6MWT walking distance at 3 months after the intervention was higher than that before the intervention, 4 weeks after the intervention and 8 weeks after the intervention(P < 0.05).The change of 6MWT walking distance in the control group showed a downward trend during the intervention(P < 0.01).ConclusionsThe graded walking exercise program can reduce CRF in patients with lung cancer undergoing chemotherapy, effectively increase the 6MWT walking distance after intervention, and the effect is obvious at the beginning of 8 weeks of intervention.