牙周炎患者基础治疗前后牙周临床指标及炎症相关指标的对比研究

目的探讨牙周炎患者牙周基础治疗前与治疗后牙周临床指标及炎症相关指标的变化。 方法选取2019年1月至2020年12月在喀什地区第一人民医院口腔科就诊的Ⅱ期B级牙周炎患者45例，再选取同期年龄、性别匹配的健康人群45例列入健康组进行对照。比较牙周炎组治疗前与健康组的牙周临床指标探诊深度（PD）、附着水平（AL）和出血指数（BI），以及炎症相关指标血红蛋白清道夫受体（CD163）、血红素加氧酶1（HO-1）和超敏C-反应蛋白（hs-CRP）的水平；比较牙周炎组治疗前与治疗后牙周临床指标、CD163、HO-1及hs-CRP间的水平变化，并进行Pearson相关检验以探讨牙周炎患者临床指标与炎症相关指标的相关性。 结果治疗前牙周炎组PD、AL及BI均高于健康组人群，差异有统计学意义（P<0.001）；牙周炎组龈沟液CD163、外周血液CD163、龈沟液HO-1水平、外周血液HO-1水平及血清中hs-CRP水平均高于健康人群，差异有统计学意义（P<0.001）。牙周炎组PD、AL临床指标及BI评分在治疗后第1、3和6个月逐步降低，差异有统计学意义（P<0.001）。牙周炎组龈沟液、外周血液CD163、龈沟液HO-1、外周血液HO-1及血清中hs-CRP水平在治疗后第1、3和6个月逐步降低，差异有统计学意义（P<0.001）。Pearson相关性分析结果显示，治疗前与治疗后第1、3和6个月PD、AL临床指标及BI评分与龈沟液、外周血液CD163、HO-1水平及血清中hs-CRP水平正相关（P<0.05）。 结论牙周炎患者经牙周基础治疗后牙周临床指标及炎症相关指标明显好转，牙周临床指标与炎症相关指标正相关，炎症相关指标可作为牙周炎的效果评价。

Comparative study of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after basic treatment

ObjectiveTo investigate the changes of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after periodontal basic treatment. MethodsA total of 45 patients with stage Ⅱ grade B periodontitis who were treated in the Department of Stomatology, the First People′s Hospital of Kashgar from January 2019 to December 2020 were selected, and 45 age-and sex-matched healthy people in the same period were selected as the healthy group for control. The depth of probing (PD) , attachment level (AL) and bleeding index (BI) , as well as the levels of CD163, heme oxygenase-1 (HO-1) and high-sensitivity C-reactive protein (hs-CRP) were compared between the periodontitis group and the healthy group before treatment. The changes before and after treatment in the periodontal clinical indicators, as well as the levels of CD163, HO-1 and hs-CRP in the periodontitis group were examined, and the correlation between clinical indicators and inflammatory indicators in the periodontitis patients was explored. Pearson correlation test was used for correlation analysis. ResultsThe PD, AL and BI score of the periodontitis group were higher than those of the healthy group before treatment, and the differences were statistically significant (P<0.001) . The levels of CD163, HO-1 and hs-CRP in the periodontitis group were higher than those in the healthy people, and the differences were statistically significant (P<0.001) . Besides, CD163, HO-1, hs-CRP, PD, AL and BI gradually decreased at the three timepoints (1, 3, and 6 month) , and the difference was statistically significant (P<0.001) . The results of Pearson correlation analysis showed that the PD, AL and BI were positively correlated with the levels of CD163, HO-1 and hs-CRP before treatment and at 1, 3 and 6 months after treatment (P<0.05) . ConclusionsThe periodontal clinical indexes and inflammatory indexes of patients with periodontitis were significantly improved after periodontal basic treatment. There was a positive correlation between the periodontal clinical indexes and inflammatory indexes. Inflammatory indexes can be used as the indicators when evaluating the effect of periodontal treatment.