艾普拉唑与奥美拉唑治疗老年人消化性溃疡的疗效比较

目的比较艾普拉唑与奥美拉唑治疗老年消化性溃疡的疗效。 方法选取2020年4月至2021年4月在广元市中心医院确诊的老年消化性溃疡患者78例，其中39例采用奥美拉唑+阿莫西林+呋喃唑酮治疗（对照组），余39例采用艾普拉唑+阿莫西林+呋喃唑酮治疗（观察组），均持续治疗14 d。比较两组患者治疗后的临床疗效、幽门螺旋杆菌（Hp）清除率，以及治疗前后血管生长因子、炎症因子、胃肠动力学水平，并记录不良反应发生情况。计数资料的比较采用χ²检验，计量资料的比较采用t检验。 结果观察组治疗后的总有效率和Hp清除率均明显高于对照组（χ²=5.186、4.337，P<0.05）。治疗后，与对照组比较，观察组血管内皮生长因子和碱性成纤维细胞生长因子水平升高更加显著（t=5.189、5.306，P<0.01）；IL-17、IL-10、一氧化氮水平下降更加显著（t=5.207、3.190、5.643，P<0.01）；胃泌素、生长抑素、胃动素水平改善更加显著（t=6.370、4.510、3.195，P<0.01）。两组患者不良反应发生率的差异无统计学意义（χ²=0.557，P>0.05）。 结论艾普拉唑治疗老年消化性溃疡的疗效优于奥美拉唑，可提高Hp清除率和血管生长因子水平，降低炎症因子水平，改善胃动力，促进损坏黏膜修复。

Efficacy comparison of eprazole and omeprazole in the treatment of peptic ulcer in the elderly

ObjectiveTo compare the efficacy of eprazole and omeprazole in the treatment of elderly patients with peptic ulcer. MethodsA total of 78 elderly patients with peptic ulcer diagnosed in Guangyuan Central Hospital during April 2020 and April 2021 were selected. Among them, 39 patients were treated with omeprazole + amoxicillin + furazolidone (control group), and 39 patients were treated with eprazole + amoxicillin + furazolidone (observation group), both treatments lasted for 14 days. The clinical efficacy, clearance rate of Helicobacter pylori (Hp), levels of vascular growth factors, inflammatory factors and gastrointestinal dynamics before and after treatment were compared between the two groups, and adverse reactions were recorded. Chi-square test was used for comparison of counting data groups, t test was used for comparison of measurement data. ResultsThe total effective rate and Hp clearance rate of observation group were significantly higher than those of control group (χ²=5.186, 4.337, P < 0.05). After treatment, compared with the control group, the levels of vascular endothelial growth factor and basic fibroblast growth factor in the observation group increased more significantly (t=5.189, 5.306, P < 0.01); the levels of IL-17, IL-10 and nitric oxide in the observation group decreased significantly (t=5.207, 3.190, 5.643, P < 0.01); the levels of gastrin, somatostatin and motilin in the observation group were significantly improved (t=6.370, 4.510, 3.195, P < 0.01). There was no significant difference in the incidence of adverse reactions between the two groups (χ²=0.557, P > 0.05). ConclusionThe efficacy of eprazole in the treatment of senile peptic ulcer is better than omeprazole, which can improve Hp clearance rate and vascular growth factor level, reduce inflammatory factor level, improve gastric motility and promote damaged mucosa repair.