6494例妇科门诊病人子宫颈人乳头瘤病毒基因型分析

目的：分析南京地区妇科门诊病人感染宫颈人乳头瘤病毒(HPV)基因型的分布特征，为宫颈癌的防治提供支持。方法：通过医院信息系统采集数据，分析妇科门诊经宫颈脱落细胞HPV基因型检测的病人6 494例相关数据。结果：6 494例受试病人中HPV感染阳性1 882例，阳性率为28.98%。不同年龄组HPV感染阳性率间差异有统计学意义(P<0.01),其中≤19岁组HPV感染阳性率为74.70%(62/83),均高于其他年龄组(P<0.05)。受试病人以单一HPV感染(1 199/6 494,18.46%)为主，不同年龄段病人的单一HPV感染率间差异无统计学意义(P>0.05),而双重和多重HPV感染率间差异均有统计学意义(P<0.01)。受试病人以高危型HPV感染率为主(21.96%,1 426/6 494);24种基因型的HPV中，总体感染率排名前5位依次为HPV52、HPV16、HPV58、HPV51、HPV42,其中除HPV35感染率在各年龄组间差异无统计学意义外(P>0.05),其他各HPV基因型感染率在不同年龄组间差异均有统计学意义(P<0.05～...

Analysis of cervical HPV genotypes in 6 494 gynecological outpatients

ObjectiveTo analyze the distribution characteristics of cervical human papillomavirus(HPV) genotypes in gynecological outpatients in Nanjing, so as to provide support for the prevention and treatment of cervical cancer.MethodsThe data of 6 494 patients with HPV genotype detected by cervical exfoliated cells in gynecological clinic were analyzed by collecting data from hospital information system.ResultsA total of 1 882 of 6 494 patients were positive for HPV infection, and the positive rate was 28.98%.There was significant difference in the positive rate of HPV infection among different age groups(P < 0.01).The positive rate of HPV infection in the group ≤ 19 years old was 74.70%(62/83), which was higher than that in other age groups(P < 0.05).The main patients were single HPV infection(1 199/6 494, 18.46%).There was no significant difference in the rate of single HPV infection among patients of different ages(P>0.05), but there was significant difference in the rate of double and multiple HPV infection(P < 0.01).The infection rate of high-risk HPV was the main type of patients(21.96%, 1 426/6 494).Among the 24 genotypes of HPV, the top five overall infection rates were HPV52, HPV16, HPV58, HPV51 and HPV42.There was no significant difference in HPV35 infection rate among different age groups(P>0.05), but the infection rate of other HPV genotypes had statistical significance among different age groups(P < 0.05 to P < 0.01).ConclusionsBy clarifying the genotype distribution characteristics of HPV infection in local outpatients, it can provide a certain reference basis for the treatment and prevention of cervical cancer.