18F-FDG PET-CT评估乳腺浸润性导管癌临床及病理特征的研究

目的评估18F-脱氧葡萄糖正电子发射计算机断层扫描(18F-FDG PET-CT)代谢参数与乳腺浸润性导管癌临床病理学特征的关系。方法回顾性分析术前行18F-FDG PET-CT扫描且经病理学确诊为浸润性导管癌的40个病灶，测量最大标准摄取值(SUVmax)、平均标准摄取值(SUVmean)、肿瘤代谢体积(MTV)并计算糖酵解总量(TLG)。结果40个浸润性导管癌中，孕激素受体(PR)(-)组SUVmax和MTV高于PR(+)组，雌激素受体(ER)(-)组SUVmax、SUVmean、MTV和TLG均高于ER(+)组，表皮生长因子受体-2(HER-2)(-)组MTV低于HER-2(+)组，T1~T2期肿瘤的SUVmax、SUVmean、TLG和MTV均小于T3~T4期，有腋窝淋巴结转移病例的SUVmax、SUVmean和TLG均高于无腋窝淋巴结转移病例(P < 0.05~P < 0.01)。原发灶的SUVmax、MTV与Ki-67表达呈正相关关系(P < 0.01)。腋窝淋巴结的SUVmax与原发灶Ki-67表达呈正相关关系(P < 0.01)。结论18F-FDG PET-CT代谢参数能够评估乳腺浸润性导管癌的临床病理特征。

Study on the value of 18F-FDG PET-CT in the evaluation of the clinical and pathological features of invasive ductal carcinoma of breast

ObjectiveTo evaluate the relationship between the metabolic parameters of 18F-deoxyglucose positron emission computed tomography(18F-FDG PET-CT) and clinical and pathological characteristics of invasive ductal carcinoma of breast.MethodsThe clinical data of 40 primary lesions of invasive ductal carcinoma of breast diagnosed by pathology and scanned by 18F-FDG PET-CT before operation were retrospectively analyzed.The max of standardized uptake value(SUVmax), mean of standardized uptake value(SUVmean) and metabolic tumor volume(MTV) of lesions were measured, and the total lesion glycolysis(TLG) of lesions were calculated.ResultsThe SUVmax and MTV of the PR(-) group were higher than those of the PR(+) group.The SUVmax, SUVmean, TLG and MTV of the ER(-) group were higher than those of the ER(+) group.The MTV of the HER-2(-) group was lower than that of HER-2(+) group, the SUVmax, SUVmean, TLG and MTV of the stage T1-T2 tumors were less than those of the stage T1-T2 tumors, and the SUVmax, SUVmean, TLG and MTV in cases with axillary lymph node metastasis were higher than those in cases without axillary lymph node metastasis(P < 0.05 to P < 0.01).The SUVmax and MTV were positively correlated with the expression of Ki-67 in primary lesions(P < 0.01).The SUVmax of axillary lymph nodes was positively correlated with the expression of Ki-67 in the primary lesions(P < 0.01).ConclusionsThe 18F-FDG PET-CT metabolic parameters can evaluate the biological and clinical characterstics of invasive ductal carcinoma of breast.