稳心颗粒联合尼可地尔对STEMI病人行急诊PCI术后室性心律失常的影响

目的探讨稳心颗粒联合尼可地尔对ST段抬高型心肌梗死（ST segment elevation myocardial infarction，STEMI）病人行急诊经皮冠状动脉介入治疗（PCI）后室性心律失常的影响。方法选取120例行急诊PCI的STEMI病人作为研究对象，采用随机数字表法将病人分为对照组、稳心颗粒组、尼可地尔组和联合组，各30例。比较4组病人术后3 d室性心律失常发生情况，术前，术后6、24、48、72 h的QT间期离散度（QTd）和校正的QT间期离散度（QTcd）。结果联合组、稳心颗粒组、尼可地尔组室性期前收缩、非持续性室性心动过速+心室颤动的发生率均低于对照组，差异有统计学意义（P < 0.05），联合组室性期前收缩、非持续性室性心动过速+心室颤动的发生率明显低于稳心颗粒组和尼可地尔组，差异均具有统计学意义（P < 0.05）。4组病人术前的QTd和QTcd比较差异无统计学意义（P>0.05）。联合组术后6、24、48、72 h的QTd和QTcd均明显低于对照组、稳心颗粒组和尼可地尔组（P < 0.01）。结论稳心颗粒联合尼可地尔可有效降低行急诊PCI的STEMI病人的室性心律失常发生率，可缩短QTd和QTcd。

Effect of Wenxin granule combined with nicorandil on the ventricular arrhythmia in STEMI patients after emergency PCI

ObjectiveTo investigate the effects of Wenxin granule combined with nicorandil on ventricular arrhythmia in ST segment elevation myocardial infarction(STEMI) patients after emergency percutaneous coronary intervention(PCI).MethodsOne hundred and twenty STEMI patients treated with emergency PCI were randomly divided into the control group, Wenxin granule group, nicorandil group and combination group(30 cases in each group).The incidence rates of ventricular arrhythmia were compared among the four groups after 3 days of operation, and the QT interval dispersion(QTd) and corrected QT interval dispersion(QTcd) in fours groups before operation, after 6, 24, 48 and 72 h of operation were analyzed.ResultsThe incidence rates of ventricular premature systole and unsustainable ventricular tachycardia/ventricular fibrillation in combination group, Wenxin granule group and nicorandil group were significantly lower than those in control group(P < 0.05).The incidence rates of ventricular premature systole and unsustainable ventricular tachycardia/ventricular fibrillation in combination group were significantly lower than that in Wenxin granule group and nicorandil group(P < 0.05).The differences of the preoperative QTd and QTcd among four groups were not statistically significant(P>0.05).The QTd and QTcd in combination group after 6, 24, 48 and 72 h of operation were significantly lower than those in control group, Wenxin granule group and nicorandil group(P < 0.01).ConclusionsThe Wenxin granule combined with nicorandil can effectively reduce the incidence rate of ventricular arrhythmia in STEMI patients treated with emergency PCI, and shorten QTd and QTcd.