3D打印PEEK材料治疗儿童颅骨缺损的临床应用

目的分析3D打印聚醚醚酮（PEEK）在儿童颅骨修补术中的应用效果。 方法选取新疆医科大学第一附属医院小儿神经外科自2019年1月至2021年3月收治的15例颅骨缺损或颅骨肿瘤患儿（PEEK组），术前完善头颅CT薄层扫描，使用3D打印技术制备PEEK植入物，对患儿行颅骨修补术。选取同期行钛网颅骨修补的21例患儿进行对照（钛网组），对比2组患儿的年龄、性别、原发病因、颅骨缺损部位及面积，分析患儿的术中情况及术后并发症发生情况。 结果所有患儿术后切口愈合良好，1例患儿术后出现皮下积液，经穿刺抽吸并加压包扎后积液消失，1例术区少量出血，经保守治疗后好转，其余患儿无明显术后并发症。PEEK组与钛网组患儿的手术时间、术中出血量、距上次手术时间及术后并发症发生率比较，差异均无统计学意义（P>0.05）。 结论使用3D打印PEEK植入物治疗儿童颅骨缺损是可行且安全的。

Clinical application of 3D printing PEEK material in the treatment of skull defect in children

ObjectiveTo analyze the application effect of 3D printing polyetheretherketone (PEEK) material implants in children’s cranioplasty. MethodsA total of 15 pediatric patients with skull defects or skull bone tumors admitted to Pediatric Neurosurgery Department of the First Affiliated Hospital of Xinjiang Medical University from January 2019 to March 2021 were selected. The thin-layer CT scanning of the skull (PEEK group) was completed before operation, peek implants were prepared by 3D printing technology, and cranial repair was performed for the child. Meanwhile, the children who underwent titanium mesh skull repair in the same period were selected for control (titanium mesh group). The age, gender, primary cause, location and area of skull defect of the two groups were compared, and the intraoperative and postoperative complications were analyzed. ResultsThe postoperative incision healed well in all patients. One patient had subcutaneous effusion after operation, which disappeared after puncture, suction and pressure bandage. One patient had a small amount of bleeding in the operation area, which improved after conservative treatment, and the other patients had no obvious postoperative complications. There was no significant difference between PEEK group and titanium mesh group in operation time, intraoperative bleeding, time from the last operation and the incidence of postoperative complications (P>0.05). ConclusionIt is feasible and safe to apply 3D printing PEEK implant to cranioplasty for pediatric patients.