2015—2019年徐州市云龙区疑似预防接种异常反应结果监测分析

目的 了解2015—2019年云龙区疑似预防接种异常反应(AEFI)发生特征，为疫苗的安全使用提供参考依据。方法 从中国免疫规划信息系统中收集2015—2019年云龙区AEFI监测数据，采用SPSS软件进行统计分析。结果 2015—2019年云龙区累计报告AEFI病例364例，报告发生率为30.93/10万剂，其中一般反应286例(78.57%)，异常反应74例(20.33%)，偶合症4例(1.1%)，严重异常反应1例(0.27%)。4月至9月份累计报告AEFI病例236例，占报告总数的64.84%;0岁组和1岁组累计报告300例，占报告总数的82.42%。一般反应中，发热166例(58.04%)，反应时间间隔M(P₂₅～P₇₅)为9.2(5.8～16.0)h；异常反应中，过敏性皮疹36例(48.65%)，反应时间间隔M(P₂₅～P₇₅)为7.6(3.9～24.0)h。一般反应中，免疫规划疫苗AEFI报告率前三位为无细胞百白破(86.25/10万剂)、麻风疫苗(78.71/10万剂)、A群脑膜炎疫苗...

Monitoring and analysis of suspected adverse events following immunization in Yunlong District,Xuzhou City from 2015 to 2019

Objective To understand the occurrence characteristics of suspected adverse events following immunization (AEFI) in Yunlong District from 2015 to 2019, so as to provide references for the safe use of vaccines. Methods AEFI monitoring data of Yunlong District from 2015 to 2019 were collected from the China immunization planning information system, and statistical analysis was carried out by using SPSS. Results From 2015 to 2019, a total of 364 AEFI cases were reported in Yunlong District, with a reported incidence of 30.93/105 doses, including 286 cases of general reactions (78.57%), 74 cases of abnormal reactions (20.33%), 4 cases of coincidence (1.1%), and 1 case of serious abnormal reactions (0.27%). A total of 236 AEFI cases were reported from April to September, accounting for 64.84% of the total number of reports. A total of 300 cases were reported in the 0-year-old group and the 1-year-old group, accounting for 82.42% of the total number of reports. Among the general reactions, 166 cases (58.04%) had a fever, and the reaction time interval M (P25-P75) was 9.2 (5.8-16.0) h. Among the abnormal reactions, 36 cases (48.65%) had an allergic rash, and the reaction interval M (P25-P75) was 7.6 (3.9-24.0) h. In the general response, the top three in the AEFI reporting rate of immunization program vaccine were acellular pertussis (86.25/105 doses), leprosy vaccine (78.71/105 doses), and group a meningitis vaccine (65.81/105 doses). Among the abnormal reactions, the top three reported rates of AEFI of immunization program vaccines were leprosy (86.20/105 doses), mumps (20.04/105 doses), and acellular pertussis diphtheria (10.43/105 doses). The report rate of AEFI in the children‘s vaccination outpatient department (52.15/105 doses) was the highest, and the report rate of the obstetric outpatient department (1.52/105 doses) was the lowest. Conclusions The overall reporting rate of AEFI in Yunlong District from 2015 to 2019 is lower than the national level in the same period, with general reactions dominating and the incidence of serious abnormal reactions being low. In view of the low reporting rate of obstetric outpatient departments, it is necessary to strengthen personnel training and daily supervision to further improve the sensitivity of the AEFI monitoring network in the whole district.