CD3+CD20+ T cells and their roles in human diseases |
| |
Institution: | 1. Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;2. East China Military Material Purchasing Bureau, Shanghai 200433, China;3. National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China |
| |
Abstract: | CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3–5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20− T cells. Recently, emerging studies have shown a pathogenic behavior of CD3+CD20+ T cells in autoimmune diseases and CD20+ T-cell malignancies, and patients with the diseases may benefit from anti-CD20 immunotherapy to deplete these cells. However, CD3+CD20+ T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production. In this review, we will describe the current knowledge about CD3+CD20+ T-cell biology, and discuss their functional roles in autoimmune diseases as well as cancer and infectious diseases. |
| |
Keywords: | Autoimmune diseases Cancer Infectious diseases |
本文献已被 ScienceDirect 等数据库收录! |
|