宫内发育迟缓胎儿和巨大儿胎盘表皮生长因子受体表达的变化及与胎盘绒毛病理的关系

研究胎儿宫内发育迟缓（ＩＵＧＲ）和巨大儿患者胎盘上表皮生长因子受体（ＥＧＦＲ）的表达与正常妊娠胎 盘比较是否有差异，及分析其变化与胎盘绒毛发育是否有关。６０例胎盘组织标本均取自足月妊娠胎盘，于分娩后立即取 得，４％中性甲醛缓冲液固定。用免疫组织化学ＳＰ法对胎盘上ＥＧＦＲ进行测定。阳性结果及绒毛面密度和末梢绒毛血管 大小的分析和测量用多功能真彩色病理图像分析系统进行。结果，ＩＵＧＲ儿胎盘上ＥＧＦＲ的表达较正常对照组明显增加 （Ｐ＜０．００１），而巨大儿组则无明显改变（Ｐ＞０．０５）。ＩＵＧＲ胎盘末梢绒毛血管数及血管与绒毛横面积之比均明显减少（Ｐ ＜０．０１）；而在巨大儿组与对照组比较，两者均无显著性差异（Ｐ＞０．０５，Ｐ＝０．０５）。ＩＵＧＲ组和巨大儿组胎盘绒毛面密度 与对照组比较均无显著性差异（Ｐ＞０．０５）。ＩＵＧＲ儿胎盘上ＥＧＦＲ表达增加可能与其胎盘绒毛发育不良有关。提示 ＥＧＦＲ在胎儿胎盘的生长发育过程中及ＩＵＧＲ的病理过程中起重要作用。

The relationship of change of IUGR and huge infant EGFR expression and placent villus pathology

Compared IUGR and huge infant EGFR expression with normal preghant and analysed the change if or not were related with growth 60 cases organization samples were all got from pure month pregnant after childbirth, fixed with 4% neuter formaldehyde buffer solution EGFR were determined by immunohistachemistry SP method. The positive result, density and the last blood vessel size were analyzed and determined by polyfunction color pathology photo analysis system. The results were: compared with normal control, IUGR EGFR expression was signicantly increased (PRO<0.001 ), but huge infant group was no signicantly change(P>0. 05). The propotion of IUGR last blood vessel number and transverse area was decreased signicantly(p<0. 01), but huge infant group was compared with control group, Neither of them had signicant difference (P>0.05.P= 0. 05). Compared with control group, density of IUGR group and huge infant group had no signicant difference (P>0. 05). The increasing of IUGR EGFR expression perhaps was related with inadequate growth; It was suggested that EGFR could has important effect on the infant growth and development and IUGR pathology process.