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The effect of arginine vasopressin on ureagenesis in isolated rat hepatocytes |
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| Authors: | P J Drew J P Monson H K Metcalfe S J Evans R A Iles R D Cohen |
| Abstract: | The effect of arginine vasopressin (AVP) on ureagenesis was measured in isolated rat hepatocytes with ammonium chloride and L(+)-lactate as substrates. AVP was found to stimulate urea synthesis and the dose-response curve suggests that such an effect is present at concentrations of the hormone as low as 25-50 pmol/l. Both the dose-response curve and the concentrations of NH+4 employed suggest that the effect observed could be of physiological significance. |
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