结直肠癌腹腔镜切除术对机体应激反应影响的临床研究

目的　探讨结直肠癌患者行腹腔镜切除术后机体应激反应的变化。方法　选择同期腹腔镜下和常规的结直肠癌切除术患者各 30例进行前瞻性研究 ,比较两种术式术后的体温、止痛剂用量、肠蠕动恢复时间、C 反应蛋白、白细胞计数和白细胞介素 6 (IL 6 )的变化。结果　结直肠癌腹腔镜切除术组的术后体温和白细胞计数的变化与常规开腹组相比无统计学差异 ,而止痛剂用量、肠蠕动恢复时间、C 反应蛋白和术后第 1天IL 6水平均明显低于常规开腹组 (P<0 .0 1,P<0 .0 5 )。结论　结直肠癌腹腔镜切除术对机体应激反应的影响明显轻于常规开腹组 ,恢复早于常规开腹组 ,显示了微创的优越性

Effects of Laparoscopic Resection on Systemic Stress Responses in Colorectal Cancer Patients

Objective To investigate the systemic stress responses after laparoscopic resection in colorectal cancer patients.Methods Sixty patients were randomized into the laparoscopic resection group (30 cases) and open resection group (30 cases) from October 2001 to September 2002 in our hospital.Analgesic dosages, recovery time of intestinal peristalsis, postoperative temperatures, C reactive protein(CRP), IL 6 and white blood cell (WBC) counts were recorded after operation. Results The changes of postoperative temperatures and WBC counts showed no significant difference between two groups.But in the laparoscopic resection group, the recovery time of intestinal peristalsis, postoperative analgesic dosages, CRP and IL 6 significantly decreased ( P <0.01, P <0.05). Conclusion Compared with traditional open resection, laparoscopic resection of colorectal cancer can diminish the systemic stress responses and decrease the injury to patients.