| 高效液相色谱法测定萘丁美酮分散片的溶出度 |
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| 引用本文： | 谭峻英,胡盛松.高效液相色谱法测定萘丁美酮分散片的溶出度[J].中国药业,2009,18(13):28-29. |
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| 作者姓名： | 谭峻英 胡盛松 |
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| 作者单位： | 湖南中医药大学第一附属医院药剂科,湖南,长沙,410007 |
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| 摘 要： | 目的建立测定萘丁美酮分散片溶出度的高效液相色谱（HPLC）法。方法以0．5％十二烷基硫酸钠溶液为溶出介质，转速为50r／min，取样时间为45min，采用桨法测定萘丁美酮分散片的溶出度。结果萘丁美酮检测质量浓度的线性范围为20～100μg／mL（r=0．9999），平均回收率为99．56％，RSD=1．13％（n=9），3批样品45min平均溶出度均在90％以上。结论该方法操作简便，结果准确可靠。
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| 关 键 词： | 高效液相色谱法 萘丁美酮 分散片 溶出度 |
Determination of Dissolution of Nabumetone Dispersible Tablets by HPLC |
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| Tan Junying,Hu Shengsong.Determination of Dissolution of Nabumetone Dispersible Tablets by HPLC[J].China Pharmaceuticals,2009,18(13):28-29. |
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| Authors: | Tan Junying Hu Shengsong |
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| Institution: | (Department of Pharmacy, the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China 410007) |
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| Abstract: | Objective To establish a HPLC method for the dissolution determination of Nabumetone Dispersible Tablets. Methods 0. 5% SDS was taken as the solvent with the rotating speed at 50 r/min, and the sampling time was 45 min. The dissolution of Nabumetone Dispersible Tablets was determined by oar method. Results The linear range of nabumetonc was 20- 100 μg/mL（r=0. 999 9）, with the average recovery rate at 99.56% （RSD = 1.13% ）. The mean cumulative dissolutions of three batches of Nabumetone Dispersible Tablets were above 90%. Conclusion The established method is simple, accurate and reliable. |
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| Keywords: | HPLC nabumetone dispersible tablets dissolution |
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