Acquired homotypic and heterotypic immunity against oculogenital <Emphasis Type="Italic">Chlamydia trachomatis</Emphasis> serovars following female genital tract infection in mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Acquired homotypic and heterotypic immunity against oculogenital <Emphasis Type="Italic">Chlamydia trachomatis</Emphasis> serovars following female genital tract infection in mice

Authors:	Email author" target="_blank">Joseph?M?Lyons Email author Servaas?A?Morré Lucy?P?Airo-Brown A?Salvador?Pe?a James?I?Ito

Institution:	(1) Department of Infectious Diseases, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA;(2) Laboratory of Immunogenetics, Section Immunogenetics of Infectious Diseases, VU University Medical Center, Amsterdam, The Netherlands;(3) Analytical Cytometry Laboratory, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA

Abstract:	Background Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen causing female genital tract infection throughout the world. Reinfection with the same serovar, as well as multiple infections with different serovars, occurs in humans. Using a murine model of female C. trachomatis genital tract infection, we determined if homotypic and/or heterotypic protection against reinfection was induced following infection with human oculogenital strains of C. trachomatis belonging to two serovars (D and H) that have been shown to vary significantly in the course of infection in the murine model.

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