Increased expression of CD44 in hypertrophied ligamentum flavum and relevance of splice variants CD44v5 and CD44v6 |
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| Authors: | Lakemeier Stefan Schmid Raphael Foltz Lisa Rohlfs Jochen Fuchs-Winkelmann Susanne Efe Turgay Foelsch Christian Paletta Jürgen R J |
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| Institution: | (1) Department of Orthopedics and Rheumatology, University Hospital Marburg, Baldingerstrasse, 35043 Marburg, Germany;(2) Department of Neurosurgery, University Hospital Marburg, Marburg, Germany |
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| Abstract: | Background The most common spinal disorder in the elderly is lumbar spinal stenosis (LSS), which results in part from ligamentum flavum
(LF) hypertrophy. Although prior histologic and immunochemical studies have been performed in this area, the pathophysiology
of loss of elasticity and hypertrophy is not completely understood. The purpose of this immunohistological study is to elucidate
the role of CD44 and its splice variants CD44v5 and CD44v6 in the hypertrophied LF obtained from patients with lumbar spinal
stenosis (LSS). |
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