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The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats |
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| Authors: | Wen Zhang Liu-qing Di Jun-Song Li Jin-jun Shan An Kang Shuai Qian Le-tian Chen |
| Affiliation: | 1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China;2. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, PR China;3. Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, PR China;4. First Medicine School, Nanjing University of Chinese Medicine, Nanjing 210046, PR China;5. School of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China |
| Abstract: | |
| Keywords: | CD, Cortex daphnes GU, Glycyrrhizae uralenis CD&ndash GU, combination of CD and GU TCHM, traditional Chinese herbal medicine CYP, cytochrome UGT, UDP-glucuronosyltransferase Cmax, peak plasma concentration Tmax, time to Cmax AUC0&ndash t, area under the curve from 0 to time AUC0&ndash &infin , area under the curve from 0 to infinity T1/2z, terminal elimination half-life MRT, mean residence time |
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